Study on the optimal concentration of Tanreqing injection based on the mathematical model of "net benefit-concentration median"
10.3760/cma.j.issn.1673-4246.2019.09.011
- VernacularTitle: 基于"净效益-浓度组中值"数学模型的痰热清注射液最佳配液浓度范围研究
- Author:
Jue FU
1
Author Information
1. Department of Pharmacy, Xiangtan Central Hospital, Xiangtan 411100, China
- Publication Type:Clinical Trail
- Keywords:
Tan Re Qing Zhu She Ye;
Respiratory tract infections;
Net benefit/concentration;
Mathematical model;
Preparation concentration
- From:
International Journal of Traditional Chinese Medicine
2019;41(9):958-963
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the optimal concentration of Tanreqing injection for acute upper respiratory tract infections.
Methods:A retrospective analysis of 531 children with acute upper respiratory tract infection treated with Tanreqing injection was conducted. These children were divided into different groups according to concentration of Tanreqing injection (i.e., the relationship between liquid and solvent, or the dilution ratio of solvent to liquid). Assume that X was the dilution ratio of solvent to liquid and the group was divided by an additional increment of 2.5 dilution units. All the children were divided into six groups as follows, groups of A (1:10≤X<1:12.5), B (1:12.5≤X<1:15), C (1:15≤X<1:17.5), D (1:17.5≤X<1:20), E (1:20≤X<1:22.5) and F (1:22.5≤X<1:25). The clinical effective rate and incidence of adverse reactions in each group were used as clinical indicators related to concentration of Tanreqing injection. Origin 8 was used to establish the relationship between the two indicators and the median of the concentration, and to seek a net benefit index that can combine the two indicators together. Finally, the relationship between the net benefit indicator and the median of the concentration were established, and the optimal concentration was found by judging and picking up the maximum of the net benefit indicator.
Results:The relationship between the clinical effective rate and the concentration median were: Y=-0.3+31.58X-203.33X2 (R2=0.988 46), and relationship between the incidence of adverse reactions and the concentration median were: Y=-0.27+10.24X-67.85X2 (R2=0.982 28), and relationship between the net benefit indicator and the concentration median were: ΔY=-0.03+21.34X-135.48X2. The peak value of the net benefit indicator was 0.81, and the corresponding median of the concentration was 0.078 8, and the optimal dilution ratio of liquid to solvent was 1:11.6-1:14.1.
Conclusions:This article explored the optimum concentration range of Tanreqing injection and gave tips for clinical safety and effective drug use.