Clinical study of Guo's Liulian therapy in the treatment of intestinal mucosal barrier dysfunction in acute pancreatitis
10.3760/cma.j.issn.1673-4246.2019.09.002
- VernacularTitle: "郭氏六联疗法"治疗急性胰腺炎肠黏膜屏障功能障碍临床研究
- Author:
Yingjie CHEN
1
;
Hongwei ZHANG
;
Zhe CAI
;
Youni ZHANG
;
Xiaoping CHEN
;
Zhenliang WANG
;
Senren GUO
;
Yaodong ZHUANG
Author Information
1. Department of Intensive Care Unit, Jinjiang Hospital of Traditional Chinese Medicine, Jinjiang 362200, China
- Publication Type:Clinical Trail
- Keywords:
Pancreatitis, acute necrotizing;
Guo'
s Liulian therapy;
Intestinal mucosal barrier;
inflammatory factors
- From:International Journal of Traditional Chinese Medicine
2019;41(9):916-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical research of Guo's Liulian therapy in treating acute pancreatitis intestinal mucosal barrier dysfunction and provide reference for the patients with acute pancreatitis.
Methods:The 68 patients with acute pancreatitis who were admitted to our hospital from September 2016 to May 2018 were selected as study subjects. According to the random number table method, the patients were divided into the observation group and the control group, with 34 cases in each group. The patients in the control group were treated with conventional western medicine. The patients in the observation group were treated with Guo's Liulian therapy on the basis of the above treatment. The time of intestinal paralysis was compared between the two groups. The changes of intestinal mucosal barrier function and serum inflammatory factor related indexes before and after treatment were analyzed in the two groups. The difference of therapeutic effects between the two groups was observed.
Results:In the observation group, the abdominal pain relief time, abdominal distention relief time, bowel sound recovery time, and first bowel anus defecation time were significantly lower than those in the control group (t=7.621, 5.332 6.625, 8.762, all Ps<0.01). After treatment, serum LPS, DAO, ET, D-lactic acid, TNF-α, IL-1, IL-6, IL-8, and IL-10 and urine L/M were significantly lower in the observation group, while the serum ITF and MFG-E8 were significantly higher in the observation group (t=9.856, 6.974, 9.784, 16.068, 9.550, 12.506, 22.343, 16.625, 6.774, 23.469, 20.118, 23.031, all Ps<0.01).
Conclusions:The Guo's Liulian therapy treatment of acute pancreatitis in patients with intestinal mucosal barrier dysfunction can reduce the palsy remission time, reduce inflammation, increase serum ITF, MFG-E8 levels, repair of intestinal permeability, and improve the intestinal barrier function.
