Mechanism of insulin resistance in sepsis
10.3760/cma.j.issn.1673-4912.2019.09.012
- VernacularTitle: 脓毒症胰岛素抵抗的发生机制
- Author:
Huiying YAN
1
;
Youpeng JIN
Author Information
1. Department of Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
- Publication Type:Review
- Keywords:
Sepsis;
Insulin resistance;
Inflammatory factor;
Oxidative stress;
Endoplasmic reticulum stress
- From:
Chinese Pediatric Emergency Medicine
2019;26(9):696-700
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis, a systemic inflammatory response syndrome caused by infection, is a common cause of death in ICU patients.Current studies suggest that patients with sepsis have stress-induced hyperglycemia, of which insulin resistance is a direct cause.During sepsis, many factors such as increased hormone release, excessive release of inflammatory mediators and lipogenic factors, oxidative stress, and endoplasmic reticulum stress, lead to the development of insulin resistance by hindering insulin signaling and reducing insulin sensitivity.This article elaborated the mechanism of insulin resistance in sepsis from the above aspects.
