Effect of inhaled nitric oxide with mechanical ventilation in persistent pulmonary hypertension of newborn
10.3760/cma.j.issn.1673-4912.2019.09.010
- VernacularTitle: 机械通气联合一氧化氮吸入治疗新生儿持续性肺动脉高压的疗效评价
- Author:
Yang WAN
1
;
Shuqing ZHANG
2
;
Dongmei YUE
1
Author Information
1. Neonatal Department, Shengjing Hospital of China Medical University, Shenyang 110004, China
2. School of Pharmacy of China Medical University, Shenyang 110122, China
- Publication Type:Journal Article
- Keywords:
Mechanical ventilation;
Inhaled nitric oxide;
Persistent pulmonary hypertension of newborn
- From:
Chinese Pediatric Emergency Medicine
2019;26(9):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical effect of inhaled nitric oxide(iNO) with mechanical ventilation for the neonates with persistent pulmonary hypertension of newborn(PPHN).
Methods:A total of 40 neonates with PPHN poorly responding with routine treatment were treated with iNO therapy.Pulmonary artery pressure, blood gas ion analysis and respiratory function changes were observed at different time points before and after iNO.
Results:Treatment with iNO resulted in a rapid decrease in pulmonary artery pressure from(54.95±17.08) mmHg(1 mmHg=0.133 kPa) to(20.40±14.26) mmHg.Oxygenation of 40 cases improved in the first 0.5~1 hour after iNO therapy, the values of mean airway pressure(MAP)declined from(13.98±2.40)cmH2O(1 cmH2O=0.098 kPa) to(12.44±2.69)cmH2O, oxygenation index(OI)decreased from 26.89±18.62 to 13.84±5.52, PaO2/FiO2 increased from(60.34±23.49) mmHg to(144.46±23.49) mmHg, and the value of pH increased from 7.31±0.14 to 7.37±0.07.Furthermore, within 48 hours after treatment, PaO2/FiO2 and pH increased gradually, while MAP and OI decreased gradually, which all had statistical differences(P<0.01).
Conclusion:Mechanical ventilation combined with iNO therapy in the treatment of PPHN can rapidly improve the oxygenation status of neonates, reduce pulmonary vascular resistance, and then improve the survival rate and long-term prognosis.
