Clinical effect of anisodamine combined with gabapentin on painful diabetic neuropathy
10.3760/cma.j.issn.1008-6706.2019.09.014
- VernacularTitle: 山莨菪碱联合加巴喷丁治疗糖尿病痛性神经病变的疗效观察
- Author:
Jiezhong YU
1
;
Huiqing WANG
2
;
Guiying WANG
2
Author Information
1. Institute of Brain Science, Shanxi Datong University, Datong, Shanxi 037009, China
2. Department of Endocrinology, the Fifth People's Hospital of Datong, Datong, Shanxi 037006, China
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Diabetic neuropathies;
Pain;
Anisodamine;
Gabapentin;
Comparative effectiveness research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(9):1080-1083
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the clinical effect of anisodamine combined with gabapentin on painful diabetic neuropathy(PDN).
Methods:From June 2013 to February 2017, 120 patients with PDN in the Fifth People's Hospital of Datong were assigned into anisodamine group, gabapentin group and combined group according to the digital table, with 40 cases in each group, the patients were treated with anisodamine, gabapentin and combination therapy respectively.The abnormal foot plantar pressure, MCV and SCV of median nerve and common peroneus nerve, VAS and total effective rate of three groups were compared.
Results:After treatment, the indicators of the combined group were improved more significantly than those of the anisodamine group and gabapentin group in abnormal foot plantar pressure[(6.10±1.66) vs.(10.80±2.64) vs.(6.37±1.44), F=14.602, P<0.01], total effective rate (92.5% vs.62.2% vs.75.0%, χ2=10.155, P=0.006), MCV[(50.33±5.54)m/s vs.(41.12±4.47)m/s vs.(42.32±4.40)m/s, F=9.404, P=0.001], and SCV of median nerve[(48.51±6.19)m/s vs.(41.81±5.72)m/s vs.(41.76±7.17)m/s, F=3.728, P=0.037], MCV of common peroneus nerve[(40.60±5.69)m/s vs.(32.04±4.47)m/s vs.(33.52±7.76)m/s, F=5.614, P=0.009]and SCV of common peroneus nerve[(42.72±4.97)m/s vs.(36.21±6.16)m/s vs.(35.45±5.54)m/s, F=4.265, P=0.025]. After treatment, the VAS scores of the three groups decreased, which were (4.49±1.61)points, (5.82±1.58)points, (6.37±1.44)points, respectively, the difference was statistically significant(F=14.602, P=0.000), and the decrease was more significant in the combined group.
Conclusion:Compared with the anisodamine group and gabapentin group, the combined treatment is more effective on PDN.
