A historical cohort study of the survival rate difference between diabetic kidney disease and non-diabetic kidney disease maintenance hemodialysis patients
10.3760/cma.j.issn.1673-4904.2019.09.002
- VernacularTitle: 糖尿病肾病与非糖尿病肾病维持性血液透析患者生存率比较的历史队列研究
- Author:
Shuxin LIU
1
;
Rui JIN
;
Hong LIU
;
Zhihong WANG
;
Lanbo TENG
;
Cui DONG
;
Tingting GUI
;
Yu ZHANG
Author Information
1. Department of Nephrology, Dalian Municipal Central Hospital, Dalian 116033, China
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Hemodiafiltration;
Cohort studies;
Survival
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(9):771-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the survival rates difference between diabetic kidney disease (DKD) and non-DKD maintenance hemodialysis patients.
Methods:The eligible patients who started hemodialysis treatment in Dalian Municipal Central Hospital from January 1, 2010 to December 31, 2016 were enrolled. The endpoint was all-cause death. Patients were divided into two groups according to the primary disease: DKD group and non-DKD group. Survival between two groups was compared by Kaplan-Meier plots and log-rank test. Survival was timed from the start of dialysis until the date of death and was censored for the date of end of the study period (December 31, 2016). SPSS 13.0 software was used for statistical analysis. Univariate COX regression analysis was used for risk assessment. Independent analysis was performed by multivariate COX regression. P < 0.05 indicated that the difference was statistically significant.
Results:A total of 769 patients were enrolled, including 305 patients with DKD (39.7%) and 464 patients with non-DKD (60.3%). There were 465 males, accounting for 60.5%, and 304 females, accounting for 39.5%. The mean age of starting dialysis was (56.2 ± 14.9) years. The median follow-up time was 21 months. One hundred and seventy patients died due to all causes, accounting for 21.7%. The 1-, 2-, 3-, 4-, 5-, 6- and 7-year survival rates in the diabetic kidney disease group were 94%, 77%, 68%, 56%, 44%, 31% and 26%. The 1-, 2-, 3-, 4-, 5-, 6- and 7-year survival rates in the non-diabetic kidney disease group were 94%, 87%, 81%, 77%, 69%, 65% and 60%. The survival rate of DKD group was significantly lower than that of non-DKD group (χ2=23.656, P < 0.01). Multivariate Cox regression analysis showed that age of onset of dialysis, primary disease, low density lipoprotein, serum potassium, ejection fraction (EF), coronary heart disease and stroke were independent risk factors of mortality (P < 0.05).
Conclusions:The survival rate of patients with diabetic kidney disease is significantly lower than that of patients with non-diabetic kidney disease in the maintenance hemodialysis patients in our center. Age, primary disease, low density lipoprotein, EF, coronary heart disease, and stroke are independent predictors of death.
