Research progress in the role of nuclear factor-kappa B in neuropathic pain
10.3760/cma.j.issn.1008-1372.2019.09.042
- VernacularTitle: NF-κB在神经性病理疼痛中的作用研究进展
- Author:
Pihao GONG
1
;
Longfei MA
1
;
Chunyang MENG
2
Author Information
1. Clinical College, Jining Medical University, Jining 272067, China
2. Department of Spine Surgery, the Affiliated Hospital of Jining Medical University, Jining 272000, China
- Publication Type:Review
- Keywords:
NF-κ
appa B;
Neuralgia;
Neuroimmunomodulation;
Review
- From:
Journal of Chinese Physician
2019;21(9):1438-1440,f3
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain is a worldwide public health problem in which neuropathic pain (NP) caused by nerve damage is the most common chronic pain. At present, NP lacks effective treatment for any reason. In recent years, increasing studies have shown that neuroimmunity and neuroinflammation play a key role in mediating NP, and nuclear factor-kappa B (NF-κB) plays the most important role in the expression of pain inducers and effectors in the immune and inflammatory systems. NF-κB promotes transcriptional up-regulation by a promoter that links to a variety of inflammatory factors. Therefore, this paper reviews the research status of the role of NF-κB in NP.
