Meta analysis of clinical characteristics of urinary calculi in children
10.3760/cma.j.issn.1008-1372.2019.09.013
- VernacularTitle: 儿童泌尿系统结石临床特点的meta分析
- Author:
Kaihui SHEN
1
;
Lina MA
;
Dengyan WU
;
Rui MA
;
Qian CHANG
;
Yonghong YANG
Author Information
1. Department of Pediatric Nephropathy, the Second Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Journal Article
- Keywords:
Urinary calculi;
Child;
Risk factors;
Meta-analysis
- From:
Journal of Chinese Physician
2019;21(9):1339-1344,1348
- CountryChina
- Language:Chinese
-
Abstract:
Objective:We investigated the clinical characteristics and the most important risk factors of urinary calculi in children.
Methods:Using Cochrane Library, PubMed, ProQuest, ELEVIER Science Direct, Embase, Springerlink, China National Knowledge Infrastructure (CNKI), and Wanfang database, we reviewed literature on clinical characteristics of urinary calculi in children from January 2003 to September 2018, and data was analyzed using STATA 14.0.
Results:Incidence of calculi in male children was 62.1% [95% CI (57.2%, 67.1%)]. 39.4% [95% CI (26.5%, 52.2%)] children with urolithiasis had a family history of positive stones, 25.3% [95% CI (19.2%, 31.3%)] had a history of urinary infection, and 16.6% [95% CI (12.3%, 20.9%)] had abnormal urinary anatomy. In addition, urinary calculi were most commonly found in the kidney [63.6%, 95% CI (49.9%, 77.3%)], followed by ureter [17.2%, 95% CI (13.4%, 21.0%)], and bladder [12.4%, 95% CI (6.9%, 18.7%)]. The single component of urinary calculi in children accounted for 58.8% [95% CI(48.7%, 68.9%)], the most common component was calcium oxalate [49.4%, 95% CI (36.7%, 62.1%)], followed by uric acid [7.9%, 95% CI (4.1%, 11.6%)]. The most common urinary metabolic disorders were hypernatremia [38.8%, 95% CI (27.9%, 49.7%)], followed by hypercalciuria [33.4%, 95% CI (27.3%, 39.4%)].
Conclusions:Heredity metabolic abnormalities, urinary tract infection, and anatomical structural abnormalities are important risk factors of urinary calculi in children. Stone recurrence could be reduced and prevented by regulating metabolic disorders, managing urinary tract infection, and correcting anatomical abnormality.
