Effect of ABCB1 C3435T genetic polymorphism on efficacy of postoperative analgesia
10.3760/cma.j.issn.0254-1416.2019.09.015
- VernacularTitle: ABCB1 C3435T基因多态性对患者术后镇痛效果的影响
- Author:
Xueying ZHANG
1
;
Yongxin LIANG
2
;
Cuili WEN
2
;
Jing XIA
2
;
Haichen CHU
2
Author Information
1. Department of Medicine, Qingdao University, Qingdao 266000, China
2. Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao 266000, China
- Publication Type:Journal Article
- Keywords:
Polymorphism, single nucleotide;
Analgesia;
Pain, postoperative
- From:
Chinese Journal of Anesthesiology
2019;39(9):1085-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of ATP-binding cassette B subfamily member 1 transporter (ABCB1) C3435T genetic polymorphism on the efficacy of postoperative analgesia.
Methods:One hundred American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients, aged 18-60 yr, scheduled for elective thoracoscopic lobectomy under general anesthesia, were enrolled in this study.The gene mutation of ABCB1 C3435T was detected, and the patients were divided into 3 groups according to the genotypes: wild homozygote group (CC group), mutation heterozygote (CT group) and mutation homozygote group (TT group). Patient-controlled intravenous analgesia was performed with sufentanil after operation.Visual analogue scale (VAS) scores at 24 and 48 h after operation, postoperative consumption of sufentanil, sleep quality score at 24 h after operation and state-trait anxiety score were recorded.
Results:Compared with CC group, VAS scores at 24 h after operation and postoperative consumption of sufentanil were significantly decreased in TT and CT groups, and the state-trait anxiety score was significantly decreased in TT group and increased in CT group (P<0.05). Compared with TT group, VAS scores at 24 h after operation, postoperative consumption of sufentanil and the state-trait anxiety score were significantly increased in CT group (P<0.05). There was no significant difference in sleep quality scores among the three groups (P>0.05).
Conclusion:ABCB1 C3435T genetic polymorphism may be one of the mechanisms of the individual variation in the efficacy of postoperative analgesia.
