The clinical analysis of 12 patients with immunoglobulin G4 related sialoadenitis and literature review
10.3760/cma.j.issn.1007-7480.2019.09.005
- VernacularTitle: 免疫球蛋白G4相关性涎腺炎12例临床特点分析
- Author:
Xiaojie LI
1
;
Bo SHAO
2
;
Hui LIU
2
;
Zhongcheng GONG
2
Author Information
1. Oral and Maxillofacial Surgical Ward Medical Center, the Affiliated Stomatological Hospital of Soochow University, Suzhou Stomatological Hospital, Jiangsu 215000, China
2. Oral and Maxillofacial Tumor Surgical Ward Medical Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
- Publication Type:Clinical Trail
- Keywords:
Immunoglobulin G;
Sialadenitis;
Sjögren′ syndrome;
Prednisone;
Immunoglobulin G4-Related Disease;
Rituximab
- From:
Chinese Journal of Rheumatology
2019;23(9):599-604,插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics of Immunoglobulin G4 (IgG4) related sialoadenitis, to analyze the difference between the IgG4 related sialoadenitis and Sjögren′ syndrome (SS) and to summarize the treatment method and prognosis of the disease, so as to help clinical diagnosis and appro-priate treatment.
Methods:According to inclusion criteria and exclusione criteria, we collected 12 cases of IgG4 related sialoadenitis patients and 78 cases of SS patients from the First Affiliated Hospital of Xinjiang Medical University from 2015-2017. The clinical manifestations, laboratory test, pathological examinations, imaging examinations and the effects of treatment of IgG4 related sialoadenitis were retrospectively anal-yzed. Several aspects of the examination were compared with SS. The count data was analyzed by chi-square test or Fisher exact probality using Statistical program for social sciences (SPSS) 19.0 software.
Results:Character-istics of IgG4 related sialoadenitis was that one or more pairs of salivary glands and lacimal glands were enlar-ged with increasing serum IgG4 levels and IgG4+ plasma cell infiltration. Compared with SS, sialoadenitis enl-argement (12/12 vs 18/78, χ2=24.339, P<0.01), dry eyes and mouth (9/12 vs 78/78, P<0.01), serum IgG4 (12/12 vs 0/78, χ2=81.554, P<0.01), antinuclear antibodies (1/11 vs 78/78, χ2=71.030, P<0.01), anti-SSA antibody (0/9 vs 68/78,χ2=31.001, P<0.01), anti-SSB antibody (0/9 vs 36/78, χ2=5.311, P=0.021), anti-Ro-52 antibody (0/9 vs 70/78, χ2=35.824, P<0.01), infiltration of IgG4 positive plasma cell (12/12 vs 0/78, χ2=81.554, P<0.01), therapeutic efficacy of glucocorticoid (6/6 vs 0/34, P<0.01) was statistically significant.
Conclusion:IgG4 related sialoadenitis has remarkable characteristics in clinical manifestations, serology, pathology and imaging examinations. Although IgG4 related sialoadenitis and SS have many similarities, we still need to diagnose the disease as early as possible and set up a reasonable treatment plan for patients.
