The relationship between left ventricular myocardial strain and different stages of cardiac dysfunction in spontaneously hypertensive rats evaluated by two-dimensional strain echocardiography
10.3760/cma.j.issn.1004-4477.2019.09.016
- VernacularTitle: 自发性高血压大鼠左室心肌应变特点及其与心功能不全类型的关系
- Author:
Ziling YOU
1
;
Qinyun RUAN
1
;
Liyun FU
1
;
Chunyan HUANG
1
;
Lei YAN
1
;
Yupeng CHEN
2
;
Huang′e CAI
1
;
Yali CHEN
1
;
Dongmei LIN
1
;
Huizhen CHEN
1
Author Information
1. Department of Ultrasound, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
2. Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Spontaneously hypertensive rat;
Strain;
Cardiac dysfunction
- From:
Chinese Journal of Ultrasonography
2019;28(9):817-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between multi-dimensional myocardial strain and global cardiac function in different stages of cardiac dysfunction in spontaneously hypertensive rats (SHR) by two-dimensional strain echocardiography.
Methods:According to cardiac function measurements, SHR of 28 to 102 weeks were divided into 3 groups: Normal group[Group A, normal left ventricular ejection fraction(LVEF) and left ventricular end-diastolic pressure(LVEDP), n=13], diastolic dysfunction group (Group B, normal LVEF but increased LVEDP, n=24), and systolic dysfunction group (Group C, decreased LVEF and increased LVEDP, n=17), with WKY rats at similar weeks of age as controls (group a, n=7; group b, n=12; and group c, n=16). Morphological parameters of left ventricular were measured by echocardiography. Using EchoPac workstation, systolic peak longitudinal strain, circumferential and radial strain were calculated at the left ventricular middle levels. Extracellular collagen content was observed histologically.
Results:Left atrial dimension increased in group B and larger in group C, and dilated left ventricular and thickened wall were only found in group C. Systolic peak longitudinal strain of group B was significantly lower than group A and group a(all P<0.05), and deteriorated in group C(P<0.05), while systolic peak circumferential and radial strain and LVEF were only significantly decreased in group C (all P<0.05), while there was no significant difference between Group A and Group B(all P>0.05). Collagen content in endocardial and mid-layer myocardium increased in group B and C, and increased epicardial collagen occurred in group C. Systolic peak longitudinal strain, circumferential and radial strain were correlated positively with LVEF(r=0.65, 0.80, 0.80, all P<0.01).
Conclusions:In SHR, systolic peak longitudinal strain obtained by echocardiography is decreased in the period of diastolic dysfunction, while the damage of systolic peak circumferential and radial strain leads to the systolic dysfunction.
