Study on microscopic marginal extensions of malignant liver tumors based on tumor types and ultrasonic characteristics
10.3760/cma.j.issn.1004-4477.2019.09.005
- VernacularTitle: 基于超声特点及肿瘤类型的肝恶性肿瘤边缘浸润距离的研究
- Author:
Xian ZHONG
1
;
Xiaohua XIE
1
;
Jihui KANG
2
;
Bowen ZHUANG
1
;
Xiaoyan XIE
1
Author Information
1. Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University & Department of Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
2. Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
- Publication Type:Clinical Trail
- Keywords:
Ultrasonography;
Contrast-enhanced ultrasonography;
Liver tumors;
Tumor micro-invasion
- From:
Chinese Journal of Ultrasonography
2019;28(9):759-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationships between microscopic marginal extensions and tumor types, and ultrasonic characteristics of malignant liver tumors.
Methods:Two-dimensional ultrasonography, contrast-enhanced ultrasonography and ultrasound-guided biopsy of hepatic tumors and surrounding hepatic tissues were performed in 78 patients with malignant liver tumor. Pathological microscopic extensions were observed after hematoxylin-eosin staining of biopsy specimens.
Results:The microscopic marginal extension rates of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and metastatic liver cancer (MLC) were 62.5%(30/48), 87.5%(7/8), and 91.0% (20/22), respectively. For tumors with well-defined and poorly-defined two-dimensional ultrasound boundary, microscopic marginal extension rates were 50%(14/28), and 86%(43/50). Tumor type and two-dimensional ultrasound boundary were independent predictors for microscopic extension rate (P<0.05). The median microscopic extension distances of HCC, ICC and MLC were 1.0(0, 3.0)mm, 4.0(2.3, 4.0)mm, and 2.0(1.8, 4.0)mm, respectively. The distance of microscopic extension increased with tumor size. Tumor type and tumor size were independent predictors for the distance of microscopic extension (P<0.05).
Conclusions:ICC, MLC, and tumors with larger diameter or poorly-defined two-dimensional ultrasound boundary have a larger distance of microscopic extension.
