Neurocognitive profiles and related factors of subjective cognitive decline
10.3760/cma.j.issn.1674-6554.2019.09.014
- VernacularTitle: 主观认知减退老年人神经认知特征及相关因素分析
- Author:
Xiaojuan JIANG
1
;
Zhiqiang WANG
;
Degang WANG
;
Wei FENG
;
Pengpeng LI
;
Li JI
;
Jun GU
;
Li TANG
;
Hongyu YANG
;
Zaohuo CHENG
Author Information
1. Wuxi Mental Health Center of Nanjing Medical University, Wuxi 214151, China
- Publication Type:Clinical Trail
- Keywords:
Subjective cognitive decline;
Community elderly;
Neurocognition;
Risk factors
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(9):832-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the neurocognitive characteristics and related factors in the elderly with subjective cognitive decline.
Methods:Among the 1 850 elderly volunteers aged over 50, 377 cognitive normal elderly (NC group), 234 subjective cognitive decline (SCD Group) and 291 patients with mild cognitive impairment (aMCI Group) were screened with the brief elderly cognitive screening questionnaire and the elderly rapid cognitive screening scale.They were all received clinical interview and examination and core neurocognitive test.
Results:(1) There were statistically significant differences in the three groups on the age, education, occupation, HAMD, low density lipoprotein and blood pressure (P<0.01). (2) The score of the picture-symbol association in SCD group(8.94±4.05)was lower than that in NC group(9.83±4.18)and higher than that in aMCI group (7.12±4.17)(all P<0.05), while the scores of the other neuropsychological tests were higher than those in aMCI group.There were no statistically significant difference between SCD group and NC group on the other neuropsychological tests(P>0.05). (3)The SCD was mainly influenced by age(β=0.063, OR=1.065, 95%CI=1.033-1.099), depression(β=0.182, OR=1.199, 95%CI=1.084-1.327)and hypertension(β=0.473, OR=1.604, 95%CI=1.185-2.171)(all P<0.01). And the aMCI was mainly influenced by age(β=0.078, OR=1.081, 95%CI=1.048-1.115), education(β=-0.174, OR=0.840, 95%CI=0.778-0.907), occupation(β=-0.406, OR=0.666, 95%CI=0.535-0.830)and low density lipoprotein(β=-0.451, OR=0.637, 95%CI=0.497-0.816)(all P<0.01 ).
Conclusion:Objective neurocognitive function of the elderly with subjective cognitive decline is basically normal.Age, depression and hypertension are risk factors of subjective cognitive decline.
