The relationship between insulin resistance and plasma hs-CRP in patients with chronic schizophrenia
10.3760/cma.j.issn.1674-6554.2019.09.012
- VernacularTitle: 慢性精神分裂症患者胰岛素抵抗水平与血浆超敏C反应蛋白的关系
- Author:
Xiaoshuai NING
1
,
2
;
Lei XIA
1
,
2
;
Yating YANG
1
,
2
;
Juan WANG
1
,
2
;
Yelei ZHANG
1
,
2
;
Zhiwei LIU
1
,
2
;
Yulong ZHANG
1
,
2
;
Yi ZHONG
1
,
2
;
Tongtong ZHAO
1
,
2
;
Wenzheng LI
3
;
Huanzhong LIU
1
,
2
Author Information
1. Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei 238000, China
2. Anhui Psychiatric Medical Center, Hefei 238000, China
3. Hefei Fourth People's Hospital, Hefei 238000, China
- Publication Type:Clinical Trail
- Keywords:
Chronic schizophrenia;
Hypersensitive reactive protein;
Insulin resistance;
Homeostasis model assessment-IR
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(9):822-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between insulin resistance and plasma hypersensitive reactive protein (hs-CRP) in patients with chronic schizophrenia.
Methods:A total of 247 inpatients with chronic schizophrenia (patient group) and 166 cases of normal individuals(control group) were enrolled.Their general demographic and clinical data were collected, fasting blood glucose, hs-CRP, c-peptide and insulin indexes were tested, and insulin resistance index (HOMA-IR) was calculated.The insulin resistance level of the patients group and the control group was compared by Mann-Whitney U test, and the relationship between insulin-resistance and hs-CRP in patients group was analyzed using Spearman correlation analysis.
Results:(1)The levels of C-peptide (2.53(2.06, 3.23)ng/ml vs 2.24(1.89, 2.87)ng/ml), insulin (7.68(4.66, 11.97)μIU/ml vs 7.02(4.31, 9.59)μIU/ml) and HOMA-IR (1.75(1.09, 3.07) vs 1.57(0.97, 2.22)) in the patient group were significantly higher than those in the control group(all P<0.05). (2) The levels of HOMA-IR( 1.91(1.21, 3.74) vs 1.70(1.02, 2.72)) in patients with high hs-CRP(≥3 mg/L) was higher than those in the patients with low hs-CRP(<3 mg/L)(P<0.05). (3)Spearman correlation analysis showed that HOMA-IR was positively correlated with plasma hs-CRP level in the patient group (r=0.139, P<0.05). (4)After logarithmic transformation of related variables, multivariate linear regression analysis showed that HOMA-IR was linearly correlated with hs-CRP level and boy weight index.
Conclusion:The hs-CRP level in chronic schizophrenia has a positive predictive effect on insulin resistance.Detection of hs-CRP level in schizophrenic patients is helpful to assess metabolic risk of insulin.
