The relationship between insulin resistance and plasma hs-CRP in patients with chronic schizophrenia
10.3760/cma.j.issn.1674-6554.2019.09.012
- VernacularTitle: 慢性精神分裂症患者胰岛素抵抗水平与血浆超敏C反应蛋白的关系
- Author:
Xiaoshuai NING
1
;
Lei XIA
1
;
Yating YANG
1
;
Juan WANG
1
;
Yelei ZHANG
1
;
Zhiwei LIU
1
;
Yulong ZHANG
1
;
Yi ZHONG
1
;
Tongtong ZHAO
1
;
Wenzheng LI
2
;
Huanzhong LIU
1
Author Information
1. Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei 238000, China; Anhui Psychiatric Medical Center, Hefei 238000, China
2. Hefei Fourth People's Hospital, Hefei 238000, China
- Publication Type:Clinical Trail
- Keywords:
Chronic schizophrenia;
Hypersensitive reactive protein;
Insulin resistance;
Homeostasis model assessment-IR
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(9):822-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between insulin resistance and plasma hypersensitive reactive protein (hs-CRP) in patients with chronic schizophrenia.
Methods:A total of 247 inpatients with chronic schizophrenia (patient group) and 166 cases of normal individuals(control group) were enrolled.Their general demographic and clinical data were collected, fasting blood glucose, hs-CRP, c-peptide and insulin indexes were tested, and insulin resistance index (HOMA-IR) was calculated.The insulin resistance level of the patients group and the control group was compared by Mann-Whitney U test, and the relationship between insulin-resistance and hs-CRP in patients group was analyzed using Spearman correlation analysis.
Results:(1)The levels of C-peptide (2.53(2.06, 3.23)ng/ml vs 2.24(1.89, 2.87)ng/ml), insulin (7.68(4.66, 11.97)μIU/ml vs 7.02(4.31, 9.59)μIU/ml) and HOMA-IR (1.75(1.09, 3.07) vs 1.57(0.97, 2.22)) in the patient group were significantly higher than those in the control group(all P<0.05). (2) The levels of HOMA-IR( 1.91(1.21, 3.74) vs 1.70(1.02, 2.72)) in patients with high hs-CRP(≥3 mg/L) was higher than those in the patients with low hs-CRP(<3 mg/L)(P<0.05). (3)Spearman correlation analysis showed that HOMA-IR was positively correlated with plasma hs-CRP level in the patient group (r=0.139, P<0.05). (4)After logarithmic transformation of related variables, multivariate linear regression analysis showed that HOMA-IR was linearly correlated with hs-CRP level and boy weight index.
Conclusion:The hs-CRP level in chronic schizophrenia has a positive predictive effect on insulin resistance.Detection of hs-CRP level in schizophrenic patients is helpful to assess metabolic risk of insulin.
