The relationship between serum high density lipoprotein levels and cognitive function in patients with bipolar disorder
10.3760/cma.j.issn.1674-6554.2019.09.009
- VernacularTitle: 血清高密度脂蛋白水平与双相情感障碍患者认知功能的相关性
- Author:
Hongliang ZHU
1
;
Jie CHEN
1
;
Xuyuan YIN
1
;
Baohua ZHANG
2
;
Zhiren WANG
2
;
Qiufang JIA
1
;
Ke ZHENG
3
;
Xiaoli YIN
3
;
Li HUI
1
,
4
Author Information
1. Psychiatry Department, Suzhou Guangji Hospital, Suzhou 215135, China
2. Department of Psychiatry Rehabilitation, Peking University Huilonguan Clinical Medical School, Beijing 102200, China
3. Psychiatry Department, Kangning Hospital Attached to Wenzhou Medical University, Wenzhou 325035, China
4. CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, China
- Publication Type:Clinical Trail
- Keywords:
High density lipoprotein;
Bipolar disorder;
Cognition
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(9):806-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum high density lipoprotein (HDL) levels and cognitive function in patients with bipolar disorder.
Methods:A total of 99 patients with bipolar disorder were enrolled from the inpatient of Suzhou Guangji Hospital.Serum HDL levels were measured by enzymatic colourimetry.Cognitive function was assessed by the repeatable battery for the assessment of neuropsychological status (RBANS). The relationship between serum high density lipoprotein and cognitive function was analyzed by correlation analysis and stepwise multiple regression analysis.
Results:Serum HDL levels ((1.39±0.55)mmol/L)were positively correlated with the RBANS total score (68.92±12.48)(r=0.238, P=0.034) and language score(80.59±15.97) (r=0.239, P=0.033) in patients with bipolar disorder.Stepwise multiple regression analysis showed that serum HDL level was the influencing factor of total score of RBANS(β=4.791, t=2.151, P=0.035)and speech function(β=7.363, t=2.247, P=0.027).
Conclusion:Serum HDL levels can influence cognitive function, especially speech function in patients with bipolar disorder.
