Antihypertensive Effect of Ramipril in Patients with Essential Hypertension.
10.4070/kcj.1993.23.4.597
- Author:
Jung Sang SONG
;
Yang Soo KIM
;
Hye Jeon CHEONG
;
Heung Sun KANG
;
Chung Whee CHOUE
;
Kwon Sam KIM
;
Myung Shick KIM
;
Jong Hoa BAE
- Publication Type:Original Article
- Keywords:
Ramipril;
Essential Hypertension;
ACE inhibitor
- MeSH:
Angiotensin-Converting Enzyme Inhibitors;
Angiotensins;
Blood Pressure;
Cough;
Dizziness;
Female;
Heart Rate;
Humans;
Hypertension*;
Male;
Ramipril*;
Systole
- From:Korean Circulation Journal
1993;23(4):597-602
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Angiotensin converting enzyme(ACE) inhibition as a means of controlling blood pressure began in the 1970s. This increasing knowledge of ACE inhibitors has resulted in their being used with confidence in a antihyertensive therapy, combining high efficacy with very low levels of side effects. METHOD: In this study, the antihyertensive effect of ramipril was assessed in 28 patients(9 males and 19 females with mean age of 52 years)with mild-to-moderate hypertension. After a placebo run-in phase, patients received ramipril as monotherapy in a dose 2.5 to 5 mg daily for 6 weeks. RESULTS: 1) At the end of 6 weeks, ramipril induced clinically significant reduction in supine(30.1mmHg in systole, 17mmHg in diastole) and sitting(33.4mmHg in systole, 18.5mmHg in diatole)blood pressure. 2) The heart rate was similar after 6 weeks. 3) The most frequent side effect was dry cough in 6 patients(5.6%) followed by dizziness. CONCLUSION: This study indicate that ramipril is effective in the treatment of mild to moderate essential hypertension.
