Expression of CD45 in newly diagnosed multiple myeloma and the relationship with prognosis
10.3760/cma.j.issn.0253-2727.2019.09.006
- VernacularTitle: CD45在初诊多发性骨髓瘤患者的表达及预后判断中的意义
- Author:
Jie SHI
1
;
Zunmin ZHU
;
Kai SUN
;
Pingchong LEI
;
Zhongwen LIU
;
Jianmin GUO
;
Jing YANG
;
Yuzhu ZANG
;
Yin ZHANG
Author Information
1. Henan Provincial People’s Hospital, Zhengzhou 450003, China
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
CD45;
Prognosis
- From:
Chinese Journal of Hematology
2019;40(9):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of CD45 in newly diagnosed multiple myeloma (MM) and its relationship with clinical efficacy and prognosis.
Methods:This study retrospectively analyzed expression and distribution of CD45 in 130 cases of newly diagnosed MM, comparing clinical efficacy and prognosis in CD45+/CD45- groups.
Results:①The CD45+ group was 33 cases (25.38%) , and CD45- group was 97 cases (74.62%) . ②The objective remission rate (ORR) of CD45+ and CD45-group was 33.33% and 64.95%, respectively. The difference was statistically significant (P=0.002) . For patients in Bortezomib regimen, the ORR of CD45+ and CD45- group was 35.71% and 66.25%, respectively. The difference was statistically significant (P=0.005) . ③The median progress free survival (PFS) of CD45+ group and CD45- group was 29.8 (95%CI 10.0-59.0) months vs 34.5 (95%CI 6.0-69.0) months (χ2=14.59, P<0.001) and the median overall survival (OS) was 32.5 (95%CI 10.0-68.0) months vs 37.6 (95%CI 6.0-78.0) months (χ2=11.42, P=0.001) , respectively. Among the patients in bortezomib regimen, The median PFS and median OS of CD45 + group and CD45- group were 30.3 (95%CI 10.0-59.0) months vs 36.3 (95%CI 6.0-69.0) months (χ2=14.75, P=0.001) and 34.0 (95%CI 10.0-68.0) months vs 39.5 (95%CI 6.0-78.0) months (χ2=10.62, P=0.001) . ④Cox risk regression model analysis showed that serum creatinine≥176.8 μmol/L (HR=5.078, 95%CI 1.744-14.723, P=0.001) , CD45 positive (HR=14.504, 95%CI 0.168-0.42, P=0.001) , LDH≥220 IU/L (HR=1.308, 95%CI 1.16-2.417, P=0.015) were independent risk prognostic factors.
Conclusion:CD45 expression is a risk prognostic factor of MM patients. Bortezomib did not improve the poor prognosis of CD45+ MM patients.
