Clinical value of serum new molecular markers in the early diagnosis of sepsis in elderly patients with burns
10.3760/cma.j.issn.0254-9026.2019.09.014
- VernacularTitle: 血清新分子标记物对老年烧伤患者感染脓毒血症的早期诊断意义
- Author:
Jianhong ZHOU
1
;
Zhenning HAN
;
Lanfang CAI
;
Chenwang DUAN
;
Hongying LI
;
Dongmei LIU
;
Wenjun JI
Author Information
1. Department of Burn and Plastic Surgery, Tangshan Gongren Hospital, Tangshan 063000, China
- Publication Type:Journal Article
- Keywords:
Myeloid cells;
Receptors, scavenger;
Sepsis;
Early diagnosis
- From:
Chinese Journal of Geriatrics
2019;38(9):1014-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of the serum new molecular markers, soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and soluble hemoglobin scavenger receptor(sCD163), in the diagnosis of sepsis in elderly patients with burns.
Methods:A total of 58 inpatients with burns from Jun 2017 to June 2018 were enrolled in the study.Patients were divided into three groups: the sepsis group(n=12), the localized infection group(n=21)and the non-infection group(n=29). The levels of sTREM-1 and sCD163 were determined by enzyme-linked immunosorbent assays(ELISAs). The clinical diagnostic value of sTREM-1 and sCD163 was assessed by receiver operating characteristic(ROC)curve analysis.
Results:There was a statistically significant difference in the levels of sTREM-1 and sCD163 at day 1 between the three groups(F=20.994 and 38.363, P<0.01). Serum levels of sTREM-1 and sCD163 were higher in the sepsis group than in the localized infection group and the non-infection group.Serum levels of sTREM-1 and sCD163 were higher in the localized infection group than in the non-infection group.Serum levels of sTREM-1 and sCD163 were lower at day 7 than those at day 1 in all groups(F=21.242 and 41.035, P<0.01). Serum sTREM-1 levels were positively correlated with serum sCD163 levels(r=0.609, P=0.000). The AUC of sTREM-1 and sCD163 for the diagnosis of sepsis was 0.880(95%CI: 0.816~0.926).
Conclusions:Serum levels of sTREM-1 and sCD163 are elevated with increasing degrees of infection.Monitoring serum sTREM-1 and sCD163 levels is helpful for the diagnosis of sepsis in elderly patients with burns.
