Clinical significance of serum level changes of heart-type fatty acid-binding protein and S-100B protein in elderly patients with chronic heart failure
10.3760/cma.j.issn.0254-9026.2019.09.004
- VernacularTitle: 老年心力衰竭患者血清心型脂肪酸结合蛋白和S100钙结合蛋白B的变化和临床意义
- Author:
Xu CHEN
1
;
Hongbo ZHANG
2
;
Wen LI
3
;
Yao YAO
2
;
Yunyun XUE
2
;
Meijia SHEN
2
;
Liuwei ZHANG
4
;
Lichao SUN
2
Author Information
1. Department of Gastroenterology, the Earth Temple Hospital of Beijing, Beijing 100015, China
2. Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China
3. ICU, China-Japan Friendship Hospital, Beijing 100029, China
4. Department of Physique and Health, College of Sports Human Science, Beijing Sport University, Beijing 100084, China
- Publication Type:Journal Article
- Keywords:
Heart failure;
Fatty acid-binding proteins;
Calcium-binding proteins
- From:
Chinese Journal of Geriatrics
2019;38(9):971-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate serum level changes of heart-type fatty acid-binding protein(H-FABP)and S100 calcium-binding protein B(S-100B)protein in elderly patients with chronic heart failure and their clinical significance.
Methods:A total of 160 patients with chronic heart failure treated at our hospital were recruited, and 80 healthy individuals receiving regular check-ups were enrolled as normal controls.Serum levels of H-FABP and S-100B and cardiac function index scores were compared between patients with different cardiac function grades.Correlations of serum H-FABP and S-100B levels with N-terminal pro-B-type natrlure tiepeptide(NT-proBNP)and with cardiac function index scores in heart failure patients were analyzed.The sensitivity, specificity and accuracy of serum H-FABP, S-100B and NT-proBNP for heart failure detection were compared.
Results:Serum levels of H-FABP, S-100B and NT-proBNP in elderly patients with chronic heart failure were elevated with increased cardiac function grading(F=9.823, 11.573 and 13.056, P=0.013, 0.000 and 0.000), and serum levels of H-FABP, S-100B and NT-proBNP were higher in elderly patients with heart failure than in the control group(P<0.05). Serum levels of H-FABP and S-100B were positively correlated with serum NT-proBNP levels, cardiac function grading and left ventricular end-diastolic diameter(LVEDd)(r=0.527, 0.510 and 0.487, P=0.008, 0.003 and 0.002; r=0.604, 0.496 and 0.533, P=0.006, 0.005 and 0.003), and were negatively correlated with left ventricular ejection fraction(LVEF)(r=-0.536 and-0.528, P=0.005 and 0.008). The sensitivity, specificity and accuracy of serum H-FABP combined with S-100B for heart failure detection were 93.2%, 91.6% and 95.7%, respectively.
Conclusions:Serum levels of H-FABP and S-100B are high in elderly patients with heart failure, and they are correlated with serum NT-proBNP levels, cardiac function grading and LVEDd.H-FABP combined with S-100B has a high positive rate for heart failure detection.
