Clinicopathological analysis of 12 cases of children synovial sarcoma
10.3760/cma.j.issn.0529-5807.2019.09.008
- VernacularTitle: 儿童滑膜肉瘤12例临床病理学分析
- Author:
Yanfei LIU
1
,
2
;
Chao JIA
1
;
Meng ZHANG
1
;
Guangsheng CHEN
3
;
Nan ZHANG
1
;
Libing FU
1
;
Lin WANG
1
;
Lejian HE
1
Author Information
1. Department of Pathology, Beijing Children′s Hospital, Beijing 100045, China
2. Department of Pathology, Xi′an Children′s Hospital, Xi′an 710043, China
3. Department of Pathology, Xi′an Children′s Hospital, Xi′an 710043, China
- Publication Type:Journal Article
- Keywords:
Sarcoma, synovial;
Immunohistochemistry;
Pathology, molecular
- From:
Chinese Journal of Pathology
2019;48(9):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate histopathological characteristics, and differential diagnoses of childhood synovial sarcoma.
Methods:HE staining, immunohistochemical staining and fusion gene detection by FISH were performed in 12 cases of synovial sarcoma in childhood at Beijing Children′s Hospital from 2016 to 2018.
Results:There were 6 cases of biphasic type, 1 case of monophasic epithelial type, 3 cases of monophasic spindle cell type and 2 cases of poorly differentiated synovial sarcomas. EMA, CKpan, bcl-2, CD99, TLE1 and CD34 immunostain positivities were observed in 10/12, 9/12, 12/12, 10/12, 10/12 and 0/12 cases respectively. Unique INI1 immunohistochemical staining was observed in 9/12 cases. SS18-SSX gene fusion was detected in 8 of 11 cases by FISH.
Conclusions:Synovial sarcoma is rare in children. Histological morphology combined with immunohistochemistry and FISH SS18-SSX fusion gene detection are important for the diagnosis and differential diagnosis of synovial sarcoma in children.
