Clinical evaluation of endoscopic anti-reflux mucosectomy for gastroesophageal reflux disease
10.3760/cma.j.issn.1007-5232.2019.09.014
- VernacularTitle: 抗反流黏膜切除术治疗胃食管反流病的临床疗效观察
- Author:
Dezhi HE
1
;
Xiaotong WANG
;
Bingrong LIU
;
Jiansheng LI
;
Dan LIU
;
Pu ZHENG
;
Yanyan ZHENG
;
Yang CHEN
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux;
Anti-reflux mucosectomy;
Endoscopic therapy
- From:
Chinese Journal of Digestive Endoscopy
2019;36(9):682-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the efficacy and safety of the endoscopic anti-reflux mucosectomy for gastroesophageal reflux disease.
Methods:Data of 18 patients with gastroesophageal reflux disease who underwent endoscopic anti-reflux mucosectomy at the First Affiliated Hospital of ZhengZhou University from December 2015 to July 2018 were retrospectively studied. The therapeutic effects (improvement of heartburn and reflux symptoms, 24 h esophageal pH monitoring) and complications were analyzed.
Results:Anti-reflux mucosectomy was performed successfully in all patients with successful rate of 100%. ESD was performed in 8 cases and EMR in 10 cases.24 h esophageal pH monitoring results showed that the Demeester score, the time percentage of pH < 4, total reflux events and reflux times of pH < 4 with time longer than 5 minutes after treatment were significantly lower than those before treatment (20.16±9.12 VS 74.16±20.03, (2.70±0.88)% VS (6.42±1.37)%, 43.78±19.68 VS 156.56±41.22, 2.89±1.68 VS 9.89±2.95, all P<0.05). No bleeding, perforation or infection was observed after the procedure. During a follow-up period of 3-34 months, symptom relief rate was 89% (16/18). A tightened cardiac was noted in 18 cases and recovery of mucosal damage was found in 16 patients.
Conclusion:Anti-reflux mucosectomy is safe, effective and easy to operate for gastroesophageal reflux disease.
