Association between congenital heart disease and maternal disease in early pregnancy in women of childbearing age
10.3760/cma.j.issn.0254-6450.2019.09.021
- VernacularTitle: 育龄妇女孕早期患病与新生儿先天性心脏病的关联
- Author:
Minmin LI
1
;
Binyan ZHANG
;
Guoshuai SHI
;
Haiyue GUO
;
Shanshan LI
;
Wentao WU
;
Baibing MI
;
Shaonong DANG
;
Hong YAN
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Maternal disease;
Propensity score
- From:Chinese Journal of Epidemiology
2019;40(9):1130-1133
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between maternal disease in early pregnancy of women of childbearing age and congenital heart disease of neonates.
Methods:A cross-sectional design was used in this study and stratified multistage random sampling method was used. A questionnaire survey was conducted in the childbearing-aged women during 2010-2013 in Shaanxi province. Propensity score (PS) matched (1∶1) analysis was used to match participants with diseases to those without disease in early pregnancy. Through the control of the confounders step by step, a logistic regression model was established to evaluate the ORs of congenital heart disease according to the independent variable of maternal disease.
Results:A total of 28 680 pairs of mothers and infants were included in this study, the proportion of the women with disease in early pregnancy was 20.25% (5 807). After PS matching, 5 436 pairs were matched. After adjusting all confounding factors, the multivariable logistic regression analysis results showed that maternal disease (OR=1.86, 95%CI: 1.23-2.81), especially cold (OR=2.19, 95%CI: 1.46-3.28), gynecological disease (OR=4.74, 95%CI: 2.03-11.09) and diabetes (OR=14.00, 95%CI: 1.64-119.21), in early pregnancy were the risk factors for congenital heart disease of neonate.
Conclusion:In women of childbearing age, disease in early pregnancy, especially cold, gynecological disease and diabetes, can increase the risk of congenital heart disease in neonates.
