Risk factors for preterm birth, low birth weight and small for gestational age: a prospective cohort study

Zhongzhou Shen; Yawen Wang; Shuai MA; Yongle Zhan; Sansan WU; Yahui Feng; Shuya Cai; Liangkun MA; Yu Jiang

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Risk factors for preterm birth, low birth weight and small for gestational age: a prospective cohort study

VernacularTitle: 新生儿早产、低出生体重及小于胎龄的危险因素
Author: Zhongzhou SHEN ¹ ; Yawen WANG ¹ ; Shuai MA ¹ ; Yongle ZHAN ¹ ; Sansan WU ¹ ; Yahui FENG ¹ ; Shuya CAI ¹ ; Liangkun MA ² ; Yu JIANG ¹
Author Information

1. Department of Epidemiology and Health Statistics, School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
2. Department of Obstetrics and Gynecology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China
Collective Name:for the Chinese Pregnant Women Cohort Study-Peking Union Medical College Collaborative Group
Publication Type:Journal Article
Keywords: Preterm birth; Low birth weight; Small gestational age; Risk factor
From: Chinese Journal of Epidemiology 2019;40(9):1125-1129
CountryChina
Language:Chinese
Abstract: Objective:To study the relationship between exposure factors in early pregnancy and preterm birth (PB), low birth weight (LBW) and small for gestational age (SGA) of neonates.
Methods:A total of 3 172 pregnant women who were enrolled in the project of Chinese Pregnant Women Cohort Study-Peking Union Medical College (CPWCS-PUMC) from July 25, 2017 to July 24, 2018 and delivered before December 31, 2018 were selected as subjects in this study. The relationship between exposure factors in early pregnancy and adverse outcomes of neonatal delivery was analyzed by using binary logistic regression analysis.
Results:The incidence rates of PB, LBW and SGA were 4.76%, 3.53% and 5.74%, respectively. In terms of PB, the analysis results showed that the gestational weight gain (GWG) and living in northern China were protective factors, while premature rupture of membranes, gestational hypertension, dental examination or treatment within 1-3 years and family with 3-4 members were risk factors. In the respect of LBW, GWG and daily consumption of milk and dairy products were the protective factors, while premature rupture of membranes, gestational hypertension, sedentary working time more than 6 hours, dental examination or treatment within 1-3 years and passive smoking were risk factors. For SGA, baby girl, passive smoking, peanut oil consumption and unsalted taste were risk factors, while folic acid supplementation was protective factor.
Conclusion:The risk factors for PB, LBW and SGA were multifactorial, and relevant specific measures should be taken to reduce the occurrence of adverse neonatal outcomes.