Epidemiological analysis of the deaths with antiretroviral treatment among adult HIV/AIDS patients in Liangshan Yi Autonomous Prefecture from 2005 to 2015
10.3760/cma.j.issn.0254-6450.2019.09.018
- VernacularTitle: 凉山彝族自治州2005－2015年成年人艾滋病抗病毒治疗死亡病例流行病学分析
- Author:
Xue JIANG
1
;
Jiali XU
2
;
Chunnong JIKE
3
;
Gang YU
3
;
Hailiang YU
2
;
Ju WANG
3
;
Shaodong YE
2
;
Qiang LIAO
3
;
Zhongfu LIU
2
Author Information
1. The Hospital of Shunyi District, Beijing 101300, China
2. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
3. Liangshan Yi Autonomous Prefecture Center for Disease Control and Prevention, Xichang 615000, China
- Publication Type:Journal Article
- Keywords:
AIDS;
Antiretroviral therapy;
Mortality rate;
Epidemiological analysis
- From:
Chinese Journal of Epidemiology
2019;40(9):1116-1119
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the deaths with antiretroviral treatment among adult HIV/AIDS patients in Liangshan Yi Autonomous Prefecture from 2005 to 2015, in order to understand the epidemiological characteristics and to further reduce the mortality rate in Liangshan Prefecture.
Methods:The relevant information was collected through the Management Database of Antiretroviral Treatment from the National AIDS Comprehensive Prevention Information System.
Results:From 2005 to 2015, a total of 14 219 adult HIV/AIDS patients received antiretroviral treatment and 1 425 death cases were reported during the treatment. The cause of death was mainly AIDS-related diseases (58.9%), and the cumulative mortality rate was 10.02%. Gender, age, the way of infection, duration of antiretroviral therapy, clinical stage when received antiretroviral therapy, and CD4+ T lymphocyte levels were factors for the mortality rate (P<0.001). The mortality increased with older age, higher initiation clinical stage and lower level of CD4+ T lymphocyte. Among the death cases, 82.6% were male, 1 182 (82.9%) were married or cohabited, most aged between 30-39 years old (48.6%). At the initial point of receiving antiretroviral therapy, 49.7% of the cases with CD4+T lymphocytes levels< 200/μl, 61.2% of the deaths cases were>1 000 copies/ml during the last viral load test, and 16.2% of deaths were ≥500/μl in the last CD4+T lymphocyte test; 44.5% of deaths were received antiretroviral treatment within one year.
Conclusion:Early and timely antiretroviral therapy should be carried out. It is necessary to strengthen the propaganda of antiretroviral therapy and to improve the management quality of follow-up information of antiretroviral therapy case files, and to improve the medication compliance of patients.
