Application of polygenic risk scores in risk prediction and precision prevention of complex diseases: opportunities and challenges

VernacularTitle: 多基因风险评分与复杂性疾病风险预测和精准预防：机遇和挑战
Author: Dong HANG ¹ ; Hongbing SHEN
Author Information

1. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Publication Type:Journal Article
Keywords: Polygenic risk score; Genome-wide association study; Complex diseases; Precision prevention
From: Chinese Journal of Epidemiology 2019;40(9):1027-1030
CountryChina
Language:Chinese
Abstract: Along with the rapid progress in the field of human genomics, genome-wide association studies have successfully identified numerous risk loci for complex diseases. Polygenic risk scores can predict disease risk by integrating the effects of multiple susceptibility loci, and begin to show good performance for improving risk prediction, screening strategy and precision prevention. This paper briefly reviews the recent progress of polygenic risk scores in disease prevention, and summarizes the opportunities and challenges of its application.