Research of peripheral blood non-coding RNA in diagnosis of breast cancer
10.3760/cma.j.issn.1009-9158.2019.09.016
- VernacularTitle: 外周血非编码RNA在乳腺癌诊断中的研究进展
- Author:
Yongyin HE
1
;
Bin XIAO
;
Ting LEI
;
Jing QU
;
Linhai LI
;
Zhaohui SUN
Author Information
1. Department of Laboratory Medicine, General Hosipital of Southern Theatre Command of PLA, Guangzhou 510010, China
- Publication Type:Review
- Keywords:
Breast neoplasms;
RNA, untranslated;
microRNAs;
RNA, long noncoding;
Circulating microRNA;
Biomarkers, tumor
- From:
Chinese Journal of Laboratory Medicine
2019;42(9):803-806
- CountryChina
- Language:Chinese
-
Abstract:
A large amount of non-coding RNA are found existing in eukaryotic transcriptome, which play an important role in regulating the expression of genes as well as participating in physiological and pathological process of various cells.In recent years,the research of ncRNA in diagnosis of breast cancer is extremely hot. In this review, the research of three types of peripheral blood ncRNAs as breast cancer diagnostic biomarkers were reviewed, including microRNA(miRNA), long non-coding RNA(lncRNA), and circular RNA(circRNA).Also,the prospect of ncRNA in clinical research and translational medicine of breast cancer was mentioned, in order to provide a new idea for breast cancer with the discovery of diagnostic markers in early detection and the monitoring of diagnosis and treatment process.
