Research progress on the functions of exosomes in colorectal cancer
10.3760/cma.j.issn.1009-9158.2019.09.015
- VernacularTitle: 外泌体在结直肠癌领域的研究进展
- Author:
Minqi GU
1
;
Jing CHEN
;
Xudong WANG
Author Information
1. Department of Clinical Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
- Publication Type:Review
- Keywords:
Colorectal neoplasms;
Exosomes;
Biomarkers, tumor
- From:
Chinese Journal of Laboratory Medicine
2019;42(9):798-802
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are a class of extracellular vesicles that secreted by a variety of cells, with the length of 40-100 nm and a lipid bilayer membrane structure. They are often observed in multiple body fluids and are important mediators in intercellular communication. Several researches demonstrated that exosomes are closely linked to the development, invasion, metastasis, and drug resistance of colorectal cancer (CRC). In this review, the role of CRC-derived exosomes in the pathogenesis, diagnosis, prognosis and treatment of CRC were briefly summarized to provide a strategy for new therapeutic targets in CRC.
