Characteristics of 185 thyroid micropapillary carcinoma patients undergoing 131I treatment
10.3760/cma.j.issn.2095-2848.2019.09.005
- VernacularTitle: 经131I治疗的185例甲状腺微小乳头状癌临床病理特征分析
- Author:
Yahong LONG
1
;
Caixia AN
;
Wanchun ZHANG
Author Information
1. Department of Nuclear Medicine, Shanxi Academy of Medical Sciences, Shanxi Dayi Hospital, Taiyuan 030032, China
- Publication Type:Clinical Trail
- Keywords:
Thyroid neoplasms;
Carcinoma, papillary;
Radiotherapy;
Iodine radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(9):532-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical features of papillary thyroid microcarcinoma (PTMC) and non-microcarcinoma papillary thyroid carcinoma (PTC).
Methods:Clinical data of 522 patients (156 males, 366 females, age: 16-77 years) with PTC treated with 131I from January 2014 to September 2018 were analyzed retrospectively. Patients were divided into PTMC group (46 males, 139 females, age: (38.5±6.5) years; tumor diameter≤1.0 cm) and non-microcarcinoma PTC group (110 males, 227 females, age: (40.5±4.5) years; tumor diameter>1.0 cm). General information and TNM status of patients were compared. The t′ test and χ2 test were used to analyze the data.
Results:Patients was relatively young in PTMC group (t′=2.20, P<0.05), but no difference was observed in gender between 2 groups (χ2=3.45, P>0.05; mostly females). The incidence of extraglandular invasion in PTMC group was significantly lower than that in PTC group (33.51%(62/185) vs 56.08%(189/337); χ2=24.37, P<0.01), mainly in peripheral muscle/fibrous adipose tissue (χ2=11.01, P<0.01) and tracheal infiltration (χ2=5.35, P<0.05). Nodular goiter and Hashimoto′s thyroiditis were commonly shown in both groups, and the tumor distribution was bilobar and/or multi-foci. The rate of regional lymph node metastasis was higher in non-microcarcinoma PTC group (88.43% (298/337) vs 82.16% (152/185); χ2=3.94, P<0.05), and central lymph node metastasis occurred more in PTMC group (χ2=5.75, P<0.05). Besides, non-microcarcinoma PTC group was likely to involve more lymph node areas (χ2=5.69, P<0.05) and distant metastasis (9.50% (32/337) vs 2.16% (4/185); χ2=10.00, P<0.01). There were no differences of extraglandular infiltration, tumor distribution or lymph node metastasis between moderate- and high-risk PTMC and non-microcarcinoma PTC groups (χ2 values: 0.01-3.33, all P>0.05).
Conclusions:Clinical characteristics of PTC can be influenced by tumor diameter. The features of primary tumor and lymph node metastasis between patients with moderate- and high-risk PTMC and non-microcarcinoma PTC patients are similar, which suggests that 131I therapy is necessary to patients with moderate- and high-risk PTMC.
