Clinical characteristics, diagnosis and efficacy of primary lymphoepithelial carcinoma of the parotid gland
10.3760/cma.j.issn.1004-4221.2019.09.002
- VernacularTitle: 原发腮腺淋巴上皮癌临床特征与诊断及疗效分析
- Author:
Huili WANG
1
;
Xiaodong HUANG
;
Yuan QU
;
Kai WANG
;
Runye WU
;
Ye ZHANG
;
Qingfeng LIU
;
Shiping ZHANG
;
Jianping XIAO
;
Junlin YI
;
Guozhen XU
;
Li GAO
;
Jingwei LUO
Author Information
1. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Lymphoepithelial carcinoma of the parotid gland;
EB virus;
Treatment outcome
- From:
Chinese Journal of Radiation Oncology
2019;28(9):648-651
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features, diagnosis and prognosis of patients with primary lymphoepithelial carcinoma of the parotid gland.
Methods:Clinical data of 13 patients diagnosed with lymphoepithelial carcinoma of the parotid gland in our hospital from 2009 to 2017 were retrospectively analyzed. The median follow-up time was 38.5 months. All patients received radiotherapy after operation.
Results:Of 13 patients, 9 cases were male and 4 female. The median age was 33 years. At the initial diagnosis, 9 cases had primary lesions limited to the parotid gland, and 4 cases of lymph node metastases located in Ⅰb and Ⅱ regions of the neck. According to UICC2010 staging, 1 case was classified as stage Ⅰ, 1 as stage Ⅱ, 6 as stage Ⅲ and 5 as stage Ⅳ, respectively. Eleven surgically pathological specimens were tested with EBER in-situ, and 10 cases were positive for EBER. No patient died in the whole group. The 3-year overall survival rate was 100%. The 3-year progression-free survival rate was 76%. The 3-year local control rate was 92%. The 3-year metastasis-free survival rate was 84%.
Conclusions:The incidence of lymphoepithelial carcinoma of the parotid gland is relatively low. The pathological features are associated with EB virus. It is prone to present with cervical lymph node metastasis. The possibility of lymph node metastasis of nasopharyngeal carcinoma to the parotid gland should be excluded before treatment. At present, surgery combined with postoperative radiotherapy is the main treatment. The overall survival is favorable. Local recurrence and distant metastasis are the main causes of treatment failure.
