Predictors of False-Negative Results from Percutaneous Transthoracic Fine-Needle Aspiration Biopsy: An Observational Study from a Retrospective Cohort.
10.3349/ymj.2016.57.5.1243
- Author:
Young Joo SUH
1
;
Jae Hoon LEE
;
Jin HUR
;
Sae Rom HONG
;
Dong Jin IM
;
Yun Jung KIM
;
Yoo Jin HONG
;
Hye Jeong LEE
;
Young Jin KIM
;
Byoung Wook CHOI
Author Information
1. Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. khuhz@yuhs.ac
- Publication Type:Observational Study ; Original Article
- Keywords:
Fine needle aspiration;
lung cancer;
positron-emission tomography
- MeSH:
Adult;
Biopsy, Fine-Needle/*methods;
Cohort Studies;
Cytodiagnosis;
False Negative Reactions;
Female;
Humans;
Lung/pathology;
Lung Diseases/*diagnosis/pathology;
Male;
Middle Aged;
Retrospective Studies
- From:Yonsei Medical Journal
2016;57(5):1243-1251
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated factors predictive of false-negative pulmonary lesions with nonspecific benign cytology results on percutaneous transthoracic fine-needle aspiration biopsy (FNAB). MATERIALS AND METHODS: We included 222 pulmonary lesions that had a nonspecific benign result from percutaneous transthoracic FNAB between March 2005 and December 2012, and were confirmed by subsequent pathologic results or adequate clinical follow up over at least 2 years. Clinical, imaging, and biopsy procedure-related findings were compared between lesions with a final diagnosis of malignancy (false-negative) and lesions with a benign diagnosis (true-negative). Multivariate logistic regression analysis was performed to identify significant predictors of false-negatives. RESULTS: Of 222 lesions, 115 lesions were proved to be false-negatives, and 107 were true-negatives. Compared with the true-negatives, false-negative lesions showed significantly older age (p=0.037), higher maximum standardized uptake value (SUVmax) on positron emission tomography (p=0.001), larger lesion size (p=0.007), and lesion characteristics of a subsolid nodule (p=0.007). On multivariate logistic regression analysis, SUVmax, lesion size, and lesion characteristics were significant predictors of false-negative results. CONCLUSION: Among the clinical, radiologic, and procedure-related factors analyzed, high SUVmax, large lesion size, and subsolid lesions were useful for predicting malignancy in pulmonary lesions with nonspecific benign cytology results on FNAB.
