The impact of bladder filling status on the movement of uterus and the volume of organs at risk in intensity modulated radiotherapy of cervical cancer
10.3760/cma.j.issn.0254-5098.2019.09.003
- VernacularTitle: 膀胱充盈状态对宫颈癌调强放疗子宫及危及器官的影响
- Author:
Jianping MA
1
;
Xinshe XIA
;
Wenyan PAN
;
Jianli HE
;
Hongqiang YE
;
Junjie CHEN
;
Jialin WANG
;
Yong WANG
;
Xuehong BAI
;
Hong ZHE
Author Information
1. General Hospital of Ninxia Medical University, Yinchuan 750004, China
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Intensity modulated radiotherapy;
Bladder filling;
Displacement;
Organs at risk
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(9):652-657
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of bladder filling status on the movement of uterine and on the volume of organs at risk(OAR), so as to provide theoretical basis for individualized internal target volume (ITV) and planning target volume (PTV).
Methods:Simulation CT images for a total of 27 patients with locally advanced cervical cancer were acquired with empty bladder, 1.0 h after bladder filling, 1.5 h after bladder filling, respectively. The volumes of uterine corpus, cervix, OARs, CTV and PTV 1.0 h after bladder filling were delineated. The impact of bladder filling status on the displacements of cervix and corpus, volumetric changes of rectum, small intestine, and the volumes of small intestine, bladder and rectum within PTV were analyzed. The correlation between bladder filling status and uterine displacement and volume of OAR was also investigated, as well as the volume of cervix and corpus in the PTV with empty bladder and 1.5 h after bladder filling.
Results:Bladder filling status is different for individual cases. The maximum movement range of cervix and uterine body with bladder filling state was 0-3.04 cm and 0-4.31 cm respectively. The anterior displacements of corpus (F=7.818, P<0.05), the volumetric changes of blander, as well the volume of bladder and small intestine in the PTV (F=46.197, 44.609, 29.546, P<0.05) were significantly different between different bladder filling status. The bladder filling status was correlated with the displacements of the anterior of corpus, volumetric changes of small intestine, and the volumes of bladder and small intestine within the PTV (r=-0.232, -0.298, 0.915, -0.336, P<0.05). The volumes of cervix and corpus out of the PTV were significantly different between the empty bladder and 1.5 h after bladder filling (t=-1.326, -1.559, P<0.05).
Conclusions:Bladder filling status was different for individual patients. The displacements of the anterior of the corpus were significantly affected by the bladder filling status. Increasing the anterior margin of PTV was recommended. The consistency of bladder filling status was critical for the precise cervical cancer IMRT.
