Safety of yellow fever vaccine strain (Tiantan strain) in China and WHO vaccine strain 17D-213
10.3760/cma.j.issn.0254-5101.2019.09.003
- VernacularTitle: 我国黄热病疫苗株(天坛株)与WHO疫苗株17D-213的安全性研究
- Author:
Ling WANG
1
;
Na LI
2
;
Enyue FANG
1
;
Yue YIN
2
;
Yuhua LI
1
Author Information
1. Arboviruses Vaccine Division, National Institute for Food and Drug Control, Beijing 102629, China
2. Quality Atbitration Division, Beijing Institute of Biological Products Co., Ltd., Beijing 100176, China
- Publication Type:Journal Article
- Keywords:
Yellow fever;
Vaccine strain;
Intracerebral pathogenicity;
Safety
- From:
Chinese Journal of Microbiology and Immunology
2019;39(9):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the intracerebral pathogenicity of the yellow fever vaccine strains of Tiantan strain used in China and WHO vaccine strain 17D-213 in mice.
Methods:Mice of different ages and strains were intracerebrally injected with same amount of Tiantan strain and 17D-213 strain. The death and survival of mice were observed and recorded. The LD50/ml and half survival time of the two vaccine strains were compared and analyzed.
Results:There was no difference in LD50/ml between the Tiantan strain and 17D-213 strain when used through intracerebral injection in one-day-old suckling mice, 7-9 g mice or 12-14 g mice. Moreover, no significant difference in survival trend was found in 7-9 g mice or 12-14 g mice injected with the two vaccine strains. However, the two strains had statistically different influences on the survival trend of one-day-old suckling mice. The half survival time of the Tiantan strain was 11 d, while that of the WHO vaccine strain 17D-213 was 6 d. Excepting in NIH mice, no significant differences in LD50/ml were detected between the same amount of two strains in BALB/c, KM, ICR or C57 mice.
Conclusions:The yellow fever Tiantan vaccine strain and WHO vaccine strain 17D-213 have no significant difference in the intracerebral pathogenicity in mice of different ages and strains with good safety.
