Preliminary study on the safety of liver transplantation recipients with Rh blood group mismatching
10.3760/cma.j.issn.0254-1785.2019.09.010
- VernacularTitle: Rh血型错配肝移植安全性的初步探讨
- Author:
Shaohua SONG
1
;
Yanling WANG
;
Hao LIU
;
Junfeng DONG
;
Keyan SUN
;
Jiayong DONG
;
Fei TENG
;
Wenyuan GUO
;
Xiaomin SHI
;
Guoshan DING
;
Zhiren FU
Author Information
1. Department of Organ Transplantation, Changzheng Hospital, Second Military University, Shanghai 200003, China
- Publication Type:Clinical Trail
- Keywords:
Rh blood group system;
Mismatching;
Liver transplantation;
Safety;
Recipient
- From:
Chinese Journal of Organ Transplantation
2019;40(9):553-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the safety of liver transplantation recipients with Rh blood group mismatchming.
Methods:From May 2005 to December 2018, 1 546 cases of liver transplantation in our hospital were retrospectively analyzed. Among these cases, 5 cases of Rh blood group mismatched were Rh(-) recipients receiving Rh(+ ) donor liver. For each Rh blood group mismatched liver transplantation, 5 patients received the same Rh blood group liver allograft were matched according to a certain principle and were defined as Rh-mismatch group and Rh-match group respectively. The serum alanine aminotransferase (ALT), aspartate aminotransferase(AST)and creatinine(SCr)were compared between two groups at Days 7 & 14 post-operation. Serum total bilirubin(TB), gamma-glutamyl transpeptidase(GGT)were compared between two groups at Month 1, 6 & 12 post-operation. Hemoglobin (Hb)were compared between two groups Month 1, 3 & 6 post-operation. The rates of infection, vascular complications and acute rejection was also compared. Indirect antiglobulin test (IAT)was used for detecting the production of anti-RhD antibody in patients in Rh-mismatch group at Month 1, 6 & 12 post-operation.
Results:At the mentioned time, no significant inter-group difference existed in serum ALT, AST, SCr, TB, GGT and blood Hb levels(all P>0.05); Also, no significant difference existed in the incidence of infection, vascular complications or acute rejection(all P>0.05). In Rhmismatch group, 4 recipients received Rh(+ )RBC transfusion during perioperative period and no hemolytic anemia occurred after operation. Rh(D) antibody was negative at all timepoints.
Conclusions:Taking into account the rarity of Rh-negative blood group in Chinese, it is safe and feasible to carry out Rh blood group mismatched liver transplantation when donor or recipient with the same Rh blood group is not available.
