Multivariate analysis of short-term prognosis of liver transplantation in patients with end-stage liver disease
10.3760/cma.j.issn.0254-1785.2019.09.008
- VernacularTitle: 影响终末期肝病肝移植受者短期预后的多因素分析
- Author:
Wei CHEN
1
;
Aidong GU
1
;
Hai DING
1
;
Yongxiang YI
1
;
Guangshun YANG
2
Author Information
1. Department of Hepatobiliary Pancreatic Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Najing, 210003, China
2. Fifth Department of Liver Surgery, Oriental Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University, Shanghai 200438, China
- Publication Type:Clinical Trail
- Keywords:
Liver transplantation;
Prognosis;
Risk factor;
Multiplicity analysis
- From:
Chinese Journal of Organ Transplantation
2019;40(9):545-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze many indicators during perioperative period of liver transplantation in patients with end-stage liver disease, only to seek related factors that can accurately predict short-term(≤three months)outcome.
Methods:We analyzed retrospectively clinical data of consecutive patients with end-stage liver diseases undergone liver transplantation in a single treatment center. Logistic regression analysis was used to analyze the perioperative indicators including recipient gender, age, body mass index, preoperative serum albumin level, serum sodium concentration, urea nitrogen level and donor-recipient blood group, et al. Correlated factors were analyzed by the method of multivariate logistic regression. Statistical processing package was SAS 9.1.3 soft. The difference was statistically significant with P<0.05.
Results:18/165 patients died within 3 months after transplantation(mortality rate: 10.9 %). According to the result of univariate analysis, the indicators correlated with early mortality which were statistically significant were preoperative serum sodium, blood urea nitrogen, PT-INR, CTP score, MELD score and MELD-Na score. On the base of the result of Logistic multiple regression. However, only MELD-Na score was associated with 3 months prognosis(P=0.001, β=-2.510, OR=0.088, 95 % CI=0.037~0.349).
Conclusions:Preoperative MELD-Na score is an independent risk factor for short-term survival in patients with end-stage liver disease. Higher MELD-Na score is, the early mortality is higher.
