170donors infection distribution and risk factor analysis of donor-derived infection in kidney transplantation
10.3760/cma.j.issn.0254-1785.2019.09.006
- VernacularTitle: 170例供者感染流行病学分布及肾移植供者来源性感染危险因素分析
- Author:
Zhijian YANG
1
;
Shichen ZHANG
;
Yanfeng WANG
;
Qifa YE
Author Information
1. Hepatobiliary Disease Institution, Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Wuhan 430071, China
- Publication Type:Clinical Trail
- Keywords:
Renal transplantation;
Infection;
Epidemiology;
Risk factor
- From:
Chinese Journal of Organ Transplantation
2019;40(9):533-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The epidemiological investigation of donor infection and the investigation of donor-derived infection(DDI)events in kidney transplantation to provide a basis for the prevention and treatment of donor infection and donor-derived infection events.
Methods:We retrospectively reviewed 170 donors and corresponding 316 kidney recipients between January 2014 with December 2017, pre-harvest blood, sputum, urine positive and negative culture were systematically recorded. We also collected donors/recipients demographics, transplant characteristics and recipients infection data within one month and focused on patient data of DDI events. Outcomes were followed up 6 months after surgery.
Results:Infection rate in 170 donors was 67.6 %, the positive rate of Gram-negative bacteria, Gram-positive bacteria and fungal were 48.3 %, 41.2 % and 10.4 %. Nine of 170 donors were DDI(5.29 %). Positive blood culture, urine culture and donor age were independent risk factors for DDI.
Conclusions:The incidence of donor infection is high. Although a few DDI events occur, the survival rate decreased. The positive blood culture and urine culture were important risk factors for the occurrence of DDI events. Therefore, it is necessary to focus on the monitoring of some high-risk strains and donors infected by high-risk infection sites.
