Myxoid Liposarcoma with Cartilaginous Differentiation: A Case Study with Cytogenetical Analysis.
- Author:
Hyunchul KIM
1
;
Won HWANGBO
;
Sangjeong AHN
;
Suhjin KIM
;
Insun KIM
;
Chul Hwan KIM
Author Information
1. Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. chkap@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Liposarcoma, myxoid;
Cartilaginous differentiation;
Cartilage;
Heterologous component;
TLS/CHOP fusion transcript
- MeSH:
Cartilage;
Liposarcoma;
Liposarcoma, Myxoid
- From:Korean Journal of Pathology
2013;47(3):284-288
- CountryRepublic of Korea
- Language:English
-
Abstract:
Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.
