A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation.
- Author:
Wook Youn KIM
1
;
Young Sin KO
;
Tae Sook HWANG
;
Hye Seung HAN
;
So Dug LIM
;
Wan Seop KIM
;
Seo Young OH
Author Information
1. Department of Pathology, Konkuk University School of Medicine, Seoul, Korea. tshwang@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Thyroid gland;
Carcinoma, papillary;
BRAF V600E;
BRAF K601E
- MeSH:
Carcinoma;
Carcinoma, Papillary;
Factor IX;
Female;
Humans;
Thyroid Gland;
Thyroid Neoplasms
- From:Korean Journal of Pathology
2013;47(3):293-298
- CountryRepublic of Korea
- Language:English
-
Abstract:
Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
