Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria.
10.3347/kjp.2013.51.3.289
- Author:
Ying SHAN
1
;
Jun LIU
;
Yan Yan PAN
;
Yong Jun JIANG
;
Hong SHANG
;
Ya Ming CAO
Author Information
1. Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China. ymcao@mail.cmu.edu.cn
- Publication Type:Original Article
- Keywords:
Plasmodium berghei ANKA;
cerebral malaria;
CD4+CD25+Foxp3+ regulatory T cell;
age;
cytokine
- MeSH:
Aging/*immunology;
Animals;
Cytokines/genetics/metabolism;
Female;
Gene Expression Regulation;
Malaria/*immunology/*parasitology;
Mice;
Plasmodium berghei/*classification;
T-Lymphocytes, Regulatory/classification/*physiology
- From:The Korean Journal of Parasitology
2013;51(3):289-295
- CountryRepublic of Korea
- Language:English
-
Abstract:
Different functions have been attributed to CD4+CD25+Foxp3+ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-alpha, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.
