Changes of immunoglobulins and CD series in patients with Graves′ orbitopathy treated with high-dose methylprednisolone
10.3760/cma.j.issn.1000-6699.2019.09.006
- VernacularTitle: 甲强龙静脉冲击治疗Graves眼病对免疫球蛋白及CD系列的影响
- Author:
Abudukerimu BUATIKAMU
1
;
Qin LI
;
Ningjian WANG
;
Fangzhen XIA
;
Yi CHEN
;
Xiaoman CHEN
;
Chunfang ZHU
;
Jie QIAO
;
Fanfan ZHU
;
Yingli LU
Author Information
1. Department of Endocrinology and Metabolism, Shanghai Ninth People′s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
- Publication Type:Clinical Trail
- Keywords:
Graves′ orbitopathy;
Methylprednisolone;
Pulse therapy;
Immunoglobulin;
CD series
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(9):756-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of high-dose methylprednisolone intravenous pulse therapy on immunoglobulins and CD series in patients with active moderate-to-severe Graves′ orbitopathy.
Methods:Twenty-seven patients with active moderate-to-severe Graves′ orbitopathy were enrolled in this study. All the patients received iv methylprednisolone pulse therapy for 12 weeks according to the 2016 European Thyroid Association/European Group on Graves′Orbitopathy(EUGOGO) Guidelines. Serum thyroidal autoantibodies, such as thyroid-stimulating hormone receptor antibody (TRAb), anti-thyroperoxidase antibody (TPOAb), and serum immunoglobulins, such as IgG, IgE, IgA, IgM were evaluated at the baseline, at the end of 4th and 12th week. Percentages of CD3+ T cells, CD4+ T cells, CD8+ T cells and CD19+ B cells, CD16+ or CD56+ NK cells were also evaluated at each time point.
Results:TRAb, TPOA and IgE, IgG, IgA were significantly decreased both after 4th week and after 12th week (all P<0.05). Percentages of CD3+ T cells, CD4+ T cells and CD4+ /CD8+ ratio were gradually decreased after treatment. However, change of CD8+ T cells was not significant (P>0.05).
Conclusion:High-dose methylprednisolone may exert an immunosuppressive effect not only by modifying humoral and cellular immune functions, but also by decreasing serum immunoglobulins.
