Anesthetic effect of dexmedetomidine in laparoscopic D2 radical gastrectomy and its influence on hemodynamics, visual analogue scale and Ramsay sedation score after operation
10.3760/cma.j.issn.1006-9801.2019.10.005
- VernacularTitle: 腹腔镜胃癌D2根治术中右美托咪定麻醉效果及对术后血流动力学、疼痛视觉模拟评分及Ramsay镇静评分的影响
- Author:
Rihong BAI
1
;
Zhiyong JIA
;
Xiaoting ZHANG
;
Yi ZHU
;
Yanli ZHAO
;
Li ZHAO
;
Qingong ZHANG
Author Information
1. Department of Anesthesiology, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Gastrectomy;
Laparoscopy;
Lymph node excision;
Hemodynamics;
Dexmedetomidine;
Pain measurement;
Ramsay sedation score
- From:
Cancer Research and Clinic
2019;31(10):666-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the anesthetic effect of dexmedetomidine in laparoscopic D2 radical gastrectomy and its influence on hemodynamics, visual analogue scale (VAS) and Ramsay sedation score after operation.
Methods:A total of 86 patients who received laparoscopic D2 radical gastrectomy under general intravenous anesthesia in Shanxi Provincial Cancer Hospital from March 2017 to June 2017 were enrolled, and all the patients were divided into two groups by using random number table method. The observation group (43 cases) was intravenously injected with dexmedetomidine (0.6 μg/kg) before induction of general anesthesia, and the dose was changed to 0.4 μg/kg after 15 min with drug withdrawal till 30 minutes before surgery, the control group (43 cases) was given an equal volume of 0.9% normal saline. The mean arterial pressure (MAP) and heart rate change before anesthetic induction (T1), tracheal intubation time (T2), after intubation (T3), section time (T4) and the immediate time after intubation (T5) were compared between the two groups. The VAS and Ramsay scores at 1 h and 4 h after surgery and the intraoperative doses of anesthesia maintenance drugs were also compared between the two groups.
Results:The heart rate and MAP of the observation group were lower than those of the control group at the time of T1, T3-T5, the differences were statistically significant (all P < 0.05). The VAS and Ramsay scores of the observation group were better than those of the control group at 1 h and 4 h after operation, and the differences were statistically significant (all P < 0.05). The intraoperative doses of propofol and remifentanil in the observation group were (964±251) mg and (3.1±0.8) mg, respectively, which were less than those in the control group [(1 485±425) mg and (4.8±0.8) mg], the differences were statistically significant (t = 9.913, P < 0.01; t = 9.834, P < 0.01).
Conclusion:Dexmedetomidine can reduce the stress response of patients with laparoscopic D2 radical anesthesia, enhance the sedative effect, and reduce the dosage of propofol and remifentanil, therefore, it has high clinical application value.
