Progress of pathogenesis in Burkitt lymphoma
10.3760/cma.j.issn.1009-9921.2019.10.014
- VernacularTitle: 伯基特淋巴瘤发病机制的研究进展
- Author:
Er CHEN
1
;
Renzhi PEI
Author Information
1. Department of Hematology, Yinzhou People's Hospital, Medicine School of Ningbo University, Ningbo 315040
- Publication Type:Review
- Keywords:
Burkitt lymphoma;
Epigenomics;
Herpesvirus 4, human;
Molecular biology
- From:
Journal of Leukemia & Lymphoma
2019;28(10):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Burkitt lymphoma (BL) is a highly aggressive B-cell non-Hodgkin lymphoma (NHL) derived from germinal center B cells, which can be divided into endemic, sporadic and immunodeficiency-associated types. BL is characterized by c-myc deregulation due to translocation of c-myc gene to an immunoglobulin enhancer region, resulting in excessive cell proliferation and rapid tumor progression, however the dysregulation of myc alone can't explain the pathogenesis and progression of BL. With the development of molecular biology technology in recent years, the further research on molecular mechanisms of BL pathogenesis may provide a theoretical basis of for clinical diagnosis and targeted drug therapy. This review discusses the progress of pathogenesis in BL.
