Mechanism of LMO3 in tumor metastasis
10.3760/cma.j.issn.1673-4203.2019.10.014
- VernacularTitle: LMO3在肿瘤转移中的机制
- Author:
Qingyi SONG
1
;
Baobing YIN
Author Information
1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
- Publication Type:Review
- Keywords:
Neoplasm metastasis;
Molecular targeted therapy;
Transcription factors;
LIM domainonly protein 3
- From:
International Journal of Surgery
2019;46(10):705-708
- CountryChina
- Language:Chinese
-
Abstract:
The LIM domains proteins are of significance proteins of human tumors. LMO3, a member of LIM-only subclass of LIM proteins, participates in the occurrence and development in many kinds of tumors, including neuroblastoma, meningioma, lung cancer and hepatocellular carcinoma, etc. LMO3 functions as interacting with neuronal transcription factor, HUA enhancer 2, interacting with upstream gene and inhibits its transcriptional activity or directly interacting with gene signaling. As an incomparable role in processes of tumors, LMO3 contributes to huge opportunities for therapeutic targeting for the future of the field.This article focuses on the molecular mechanism of LMO3 in the process of tumor development and metastasis, and reviews its recent progress.
