Indomethacin for preventing post-endoscopic retrograd cholangiopancreatography pancreatitis by rectal administration: a Meta-analysis of randomized controlled trial
10.3760/cma.j.issn.1008-6706.2019.10.023
- VernacularTitle: 吲哚美辛直肠给药预防内镜逆行胰胆管造影术后胰腺炎随机对照试验的Meta分析
- Author:
Xuanyu JIANG
1
;
Songyang ZHONG
2
Author Information
1. Department of West Pharmacy, the People's Hospital of Quzhou, Quzhou, Zhejiang 324000, China
2. Department of Pharmacy, the People's Hospital of Quzhou, Quzhou, Zhejiang 324000, China
- Publication Type:Journal Article
- Keywords:
Indomethacin;
Administration, rectal;
Cholangiopancreatography, endoscopic retrograde;
Pancreatitis;
Placebos;
Double-blind method;
Randomized controlled trial;
Meta-analysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(10):1246-1249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the effectiveness and safety of indomethacin in preventing post-endoscopic retrograd cholangiopancreatography pancreatitis(PEP) by rectal administration.
Methods:Retrieved from PubMed, Cochrane Library, CNKI, VIP, CBM and Wanfang database, randomized blinding placebo-controlled trails about indomethacin for preventing PEP by rectal administration were included from establishment to December 2017 and comprehensively evaluated.Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, assessed the risk bias of included studies, and then Meta-analysis was performed using the RevMan 5.3 software.
Results:A total of 8 RCTs involving 3240 patients were included.The results of Meta-analysis showed that indomethacin could reduce the incidence of PEP(OR=0.57, 95% CI: 0.45-0.73, P<0.00 001) and moderate or severe PEP(OR=0.51, 95% CI: 0.30-0.85, P=0.010). The adverse reactions of indomethacin was gastrointestinal bleeding, and there was no statistically significant difference between indomethacin and placebo(OR=0.63, 95% CI: 0.25-1.52, P=0.300).
Conclusion:Indomethacin is safe and effective in reducing the incidence of PEP by rectal administration.
