Comparison of the effects of different medications in the treatment of acute onset schizophrenia
10.3760/cma.j.issn.1008-6706.2019.10.014
- VernacularTitle: 不同药物治疗急性期精神分裂症的临床效果比较
- Author:
Yongqi SHI
1
;
Huaili DENG
1
;
Junying WU
2
;
Binhong WANG
1
Author Information
1. Department of Psychiatry, Taiyuan Psychiatric Hospital, Taiyuan, Shanxi 030000, China
2. Department of Psychiatry, Taiyuan Kyushu Skin Disease Hospital, Taiyuan, Shanxi 030000, China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Ammonia sulfonis;
Olanzapine;
Ziprasidone;
Comparative effectivehess research
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(10):1208-1212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the therapeutic effect of different drug in the treatment of schizophrenia in acute stage.
Methods:From November 2014 to June 2017, 105 patients with acute schizophrenia admitted in Department of Psychiatry of Taiyuan Psychiatric Hospital and Department of Psychiatry of Jiuzhou Dermatological Hospital of Taiyuan were selected in the study.Seventy-five patients were from the Department of Psychiatry, Taiyuan Psychiatric Hospital.Thirty patients were from the Department of Psychiatry, Jiuzhou Dermatology Hospital.The patients were divided into three groups by random number method, with 35 cases in each group.A group was given amisulpride.B group was given olanzapine.C group was given ziprasidone.The PANSS score (positive symptoms, negative symptoms, mental pathological score), curative effect (cured, significantly improved, invalid), adverse events (EPS, akathisia, nausea, rapid heart beat, blurred vision, orthostatic dizziness, weight gain, total adverse events) in the three groups were observed.
Results:After treatment for 2 weeks, the positive symptoms.negative symptoms, mental pathological score in the three groups were significantly decreased (all P<0.05). The positive symptoms.negative symptoms, mental pathological score at corresponding period had no statistically significant differences among the three groups (all P>0.05). There was no statistically significant difference in therapeutic effect among the three groups (P>0.05). The occurrence of EPS of C group was significantly lower than that of B group [14.29%(5/35) vs.40.00%(14/35), χ2=5.851, P<0.05]. The incidence rate of adverse events of C group was significantly lower than that of A group and B group (χ2=5.833, 4.690, all P<0.05). However, there was no statistically significant difference in the occurrence of adverse events between A group and B group(P>0.05).
Conclusion:Amisulpride, olanzapine and ziprasidone in the treatment of acute phase of schizophrenia has good early reaction control and late curative effect.The adverse events of ziprasidone is significantly less than the other two drugs.But patients adopt which kind of drugs also need to formulate specific solutions according to individual circumstance.
