Analysis of efficacy of L-apigenin A in the treatment of Alzheimer's disease
10.3760/cma.j.issn.1008-6706.2019.10.008
- VernacularTitle: 左旋芹菜甲素治疗阿尔茨海默症的疗效分析
- Author:
Qinghua CHEN
1
;
Fengqiang ZHANG
;
Lixin LI
;
Li LING
;
Wencui XUE
Author Information
1. Department of Geriatrics, Qinhuangdao Military Hospital, Qinhuangdao Hebei 066000, China
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Brief psychiatric rating scale;
Apigenin;
Cognition;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(10):1182-1184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects L-apigenin A on Alzheimer＇s disease(AD), and analyze the correlation between MMSE and ADAS-cog scores.
Methods:From January 2009 to December 2014, 34 patients with AD were selected in Qinhuangdao Military Industry Hospital.They were treated with celery seed extract L-apigenin.The MMSE scores and ADAS-cog scores were evaluated before treatment and 18, 36 and 72 d after treatment.The correlation between MMSE scores and ADAS-cog scores was analyzed.
Results:There were statistically significant differences in the MMSE scores between 72d after treatment[(22.59±1.13)points]and before treatment[(20.53±1.42)points], 18d after treatment[(20.44±1.24)points]and 36d after treatment[(20.97±1.17)points](t=6.619, 7.473, 5.807, all P<0.05). There were statistically significant differences in ADAS-Cog scores between 72d after treatment[(17.09±1.53)points]and before treatment[(20.47±2.85)points], 18d after treatment[(20.18±2.34)points]and 36d after treatment[(20.18±2.49)points](t=6.093, 6.445, 6.165, all P<0.05). The MMSE score and ADAS-Cog score had negative correlation by Pearson analysis (r=-0.259, P=0.000).
Conclusion:L-apigenin A can significantly improve the cognitive function of patients with AD.There is significant negative correlation between the MMSE scores and ADAS-cog scores.
