The Concept and Overview of Spondyloarthritis.
10.3904/kjm.2013.85.3.229
- Author:
Mi Ryoung SEO
1
;
Han Joo BAEK
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea. baekhj@gilhospital.com
- Publication Type:Review
- Keywords:
Spondyloarthritis;
Ankylosing spondylitis;
Inflammatory back pain;
HLA-B27
- MeSH:
Cytokines;
Early Diagnosis;
Genetic Predisposition to Disease;
HLA-B27 Antigen;
Immunity, Innate;
Inflammation;
Osteogenesis;
Rheumatic Diseases;
Sacroiliitis;
Spondylitis;
Spondylitis, Ankylosing
- From:Korean Journal of Medicine
2013;85(3):229-239
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases in association with HLA-B27. They share the clinical features including sacroiliitis, spondylitis, oligoarthritis, enthesitis and extra-articular involvement. Recently ASAS proposed new classification criteria sets of axial and peripheral SpA. They were designed to include non-radiographic SpA, thus can guide the early diagnosis of disease before the structural damage occurs. SpA has a strong genetic predisposition. Non-MHC genes, such as IL23R and ERAP1, as well as HLA-B27 were confirmed as susceptibility genes through several GWAS. Major pathology in SpA is entheseal inflammation and new bone formation. Intrinsic ability of HLA-B27 to trigger innate immune response and several proinflammtory cytokines may contribute to the inflammation in SpA. New bone formation could be explained by a mechanism, partly or completely independent of the inflammatory process.
