Curative effect of minimally invasive removal of intracranial hematoma in the treatment of cerebral hemorrhage and its influence on neurological functional recovery, serum inflammatory factor levels
10.3760/cma.j.issn.1008-6706.2019.10.005
- VernacularTitle: 微创颅内血肿清除术治疗脑出血的疗效观察及对患者神经功能恢复、血清炎性因子水平的影响
- Author:
Huaibin MA
1
;
Jindan XIONG
;
Fugen YAN
;
Jiazhi LI
Author Information
1. Department of Neurosurgery, Zhejiang Xin'an International Hospital, Jiaxing, Zhejiang 314000, China
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Surgical procedures, minimally invasive;
Intracranial hematoma removal;
C-reactive protein;
Interleukin-6;
Interleukin-8;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(10):1169-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of minimally invasive intracranial hematoma removal in the treatment of cerebral hemorrhage, and its influence on neurological functional recovery, serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-8(IL-8), tumor necrosis factor-alpha (TNF-α).
Methods:From January 2016 to December 2017, 100 patients with cerebral hemorrhage admitted to Zhejiang Xin'an International Hospital were selected and randomly divided into two groups according to the digital table, with 50 cases in each group.The control group was given routine symptomatic treatment, the observation group received minimally invasive intracranial hematoma removal combined with conventional treatment.The curative effect, restoration of nerve function, the levels of hs-CRP, IL-6, IL-8 and TNF- were observed in the two groups.
Results:After treatment, the blood loss and edema volume around the hematoma in the two groups were declined significantly (t=5.74, 9.32, 7.41, 9.32, all P<0.05), and the improvements of the observation group was better than those of the control group (t=8.29, 5.28, all P<0.05). The excellent and good rate of the observation group was 90%(45/50), which was significantly higher than 72%(36/50) of the control group (χ2=3.62, P<0.05). After treatment, the NDS scores of the two group were significantly lower than those before treatment (t=4.64, 5.75, all P<0.05), the GCS scores of the two groups were significantly improved (t=5.41, 7.86, all P<0.05). The NDS score of the observation group was significantly lower than that of the control group (t=5.31, P<0.05), the GCS score of the observation group was significantly higher than that of the control group(t=3.84, P<0.05). After treatment, the levels of inflammatory factors in the two groups were significantly reduced compared with those before treatment (t=3.27, 3.75, 3.38, 3.61, 5.74, 4.39, 6.52, 8.26, all P<0.05), the levels of inflammatory factors in the observation group were significantly lower than those in the control group (t=4.37, 3.92, 8.52, 4.28, all P<0.05).
Conclusion:Minimally invasive removal of intracranial hematoma combined with conventional treatment in the treatment of patients with cerebral hemorrhage can obtain satisfactory clinical effect, can promote neural functional recovery, improve inflammatory factor levels (hs-CRP, IL-6, IL-8, TNF alpha), it is worthy of application.
