Effect of recombinant human prourokinase on P-selectin in patients with acute myocardial infarction without reflux
10.3760/cma.j.issn.1673-4904.2019.10.018
- VernacularTitle: 重组人尿激酶原对治疗急性心肌梗死发生无复流患者P选择素的影响
- Author:
Shuo LU
1
;
Xiaoqun ZHENG
2
;
Fengxia HOU
1
Author Information
1. Department of Cardiology, Center Hospital of Changchun City, Changchun 130051, China
2. Department of Cardiology, Dalian Central Hospital, Dalian 116033, China
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Myocardial reperfusion;
No reflowphenomenon;
Percutaneous coronary intervention;
Recombinant human urokinase
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(10):942-946
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of intracoronary injection of recombinant human urokinase on plasma P-selectin in AMI patients with no-reflow during acute PCI.
Methods:Ninety-two patients with acute ST-segment elevation myocardial infarction or acute non-ST-segment elevation myocardial infarction admitted to Center Hospital of Changchun City in January 2017 and December 2018 were randomly divided into two groups: 47 patients with intracoronary injection of sodium nitroprusside as control group and 45 patients with intracoronary injection of recombinant human urokinase as treatment group. Among them, 58 were males and 36 were females. The onset time was less than 12 h. The basic data, serum P-selectin, myocardial perfusion index and major adverse cardiovascular events were compared between the two groups.
Results:In the treatment group, the corrected TIMI frame number, instant TIMI grade 3 blood flow, myocardial chromogenic grade 3 blood flow, myocardial necrosis marker CTnI, serum P-selectin were significantly lower than those in the control group: 31.26 ± 4.58 vs. 35.15 ± 6.25, 71.1%(32/45) vs. 51.1%(24/47), 64.4%(29/45) vs. 55.3%(26/47), (28.46 ± 3.95) ng/ml vs. (30.18 ± 3.47) ng/ml, (13.26 ± 4.58) ng/ml vs. (15.04 ± 3.98) ng/ml, and EF function was better. In the control group. The incidence of major adverse cardiac events in the treatment group was lower than that in the control group within one month after operation, but there was no statistical significance.
Conclusions:There is no reflux in patients with AMI during PCI. Intracoronary injection of recombinant human urokinase can improve myocardial perfusion without reflux and has no effect on fibrinolytic system in vivo. It does not increase the risk of systemic hemorrhage and the incidence of serious adverse cardiovascular events.
