Investigation into the expression of c-MET in patients with lung adenocarcinomaand its prognostic correlation
10.3760/cma.j.issn.1673-4904.2019.10.011
- VernacularTitle: c-MET在肺腺癌患者中的表达及预后相关性研究
- Author:
Jing LIU
1
;
Shuli XU
;
Hongying YAO
;
Tao LIU
;
Mozhao CHENG
;
Shuhong TANG
Author Information
1. Department of Chest Physicians, Dalian 5th People′s Hospital, Dalian 116021, China
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma, bronchiolo-alveolar;
c-MET;
Disease-free survival;
Prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(10):908-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of c-MET and its prognostic correlation in patients with lung adenocarcinoma.
Methods:The clinical data and pathological specimen of patients with lung adenocarcinoma in Dalian 5th People′s Hospital from January 2006 to December 2011 were retrospectively analyzed. The expression difference of c-MET between lung adenocarcinoma tissue and normal adjacent tissues was compared. The correlation of c-MET with the pathology and clinical factors was also analyzed.
Results:A total of 82 patients were retrospective analyzed, including 82 pathological specimens of lung adenocarcinoma and 45 specimens of normal adjacent tissues. Among 53 patients with stage Ⅰ-Ⅱ lung adenocarcinoma, 31 cases had low expression of c-MET and 22 cases had high expression of c-MET. Among 29 patients with stage Ⅲ lung adenocarcinoma, 10 cases had low expression of c-MET and 19 cases had high expression of c-MET. There was a correlation between TNM stage and c-MET positive expression in lung adenocarcinoma (P=0.037). The positive expression rate of c-MET was not significantly correlated with age, sex and differentiation degree (P > 0.05). Among 82 cases of lung adenocarcinoma, 39 cases had low expression of c-MET and 43 cases had high expression of c-MET; 45 cases of para-carcinoma tissuehad low expression of c-MET. The positive expression rate of c-MET in lung adenocarcinoma tissues was significantly higher than that in para-carcinoma tissue (P < 0.01). Kaplan-Meier survival curve analysis showed that the median disease-free survival was 41.5 months in c-MET high-expression group and 55.3 months in low-expression group. The expression level of c-MET was closely related to disease-free survival in lung adenocarcinoma patients (P < 0.05).
Conclusions:The expression of c-MET is significantly increased in patients with lung adenocarcinoma. The expression level has relevance with TNM staging and prognosis.
