New insights of the pathogenesis and prognostic factors of Epstein-Barr virus-associated extranodal NK/T-cell lymphoma

VernacularTitle: EB病毒感染与结外NK/T细胞淋巴瘤发生及预后的关系
Author: Yao WANG ¹ ; Xiaopin CHEN
Author Information

1. Department of Oncology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Publication Type:Review
Keywords: Herpesvirus 4, human; Lymphoma, extranodal NK-T-cell; Review
From: Journal of Chinese Physician 2019;21(10):1595-1599
CountryChina
Language:Chinese
Abstract: Extranodal NK/T-cell lymphoma (ENKTL) is a rare, invasive extra nodal non-Hodgkin's lymphoma (NHL) that is commonly associated with Epstein-Barr virus (EBV). ENKTL is the commonest to men with no apparent immunodeficiency in Asia and South America. Except for EBV, no environmental or external factors are associated with tumorigenesis. The precise mechanism by which EBV infects NK or T cells and the role of the virus in the pathogenesis of ENKTL has not been fully deciphered. However, many recent discoveries have been identified, including disorders of cell signaling and mutations in tumor suppressor genes, which provide insight into the pathogenesis of ENKTL. Moreover, NK/T cell non-Hodgkin's lymphoma generally has a poor prognosis, and research on its prognostic factors is still ongoing. This article focuses on the pathogenesis and prognostic factors of ENKTL, and attempts to provide direction for improving patient outcomes.